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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231

  • Authors:
    • Irena Selicharova
    • Miloslav Sanda
    • Jana Mladkova
    • Sujata Saraswat Ohri
    • Aruna Vashishta
    • Martin Fusek
    • Jiri Jiracek
    • Vaclav Vetvicka

  • View Affiliations / Copyright

    Affiliations: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague, Czech Republic. selicharova@uochb.cas.cz
  • Pages: 1237-1244
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1237
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Abstract

Human MDA-MB-231 derived breast cancer cell lines 1833 and 4175 have different metastatic potentials in terms of their tissue tropisms and aggressiveness. Cell line 1833 is specifically metastatic to the bone. The highly aggressive cell line 4175 is specific to the lung. We performed 2-DE analysis of the cell lines. We found 16 significantly changed protein spots, 14 protein spots were identified. Expression of cathepsin D, triosephosphate isomerase, phosphoglycerate kinase 1, heme binding protein 1 and annexin 2 could be correlated with the in vitro aggressiveness of the respective cell lines. Interstitial collagenase and dimethylargininase 2 were exclusive to the cell line 1833 and might contribute to its bone specificity. Serpin B9, cathepsin B chain b, galectin 3 and HSP 27 were changed in the lung specific cell line 4175. The possible contribution of identified proteins to differences in metastatic behavior of the cell lines is discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Selicharova I, Sanda M, Mladkova J, Ohri SS, Vashishta A, Fusek M, Jiracek J and Vetvicka V: 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231. Oncol Rep 19: 1237-1244, 2008.
APA
Selicharova, I., Sanda, M., Mladkova, J., Ohri, S.S., Vashishta, A., Fusek, M. ... Vetvicka, V. (2008). 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231. Oncology Reports, 19, 1237-1244. https://doi.org/10.3892/or.19.5.1237
MLA
Selicharova, I., Sanda, M., Mladkova, J., Ohri, S. S., Vashishta, A., Fusek, M., Jiracek, J., Vetvicka, V."2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231". Oncology Reports 19.5 (2008): 1237-1244.
Chicago
Selicharova, I., Sanda, M., Mladkova, J., Ohri, S. S., Vashishta, A., Fusek, M., Jiracek, J., Vetvicka, V."2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231". Oncology Reports 19, no. 5 (2008): 1237-1244. https://doi.org/10.3892/or.19.5.1237
Copy and paste a formatted citation
x
Spandidos Publications style
Selicharova I, Sanda M, Mladkova J, Ohri SS, Vashishta A, Fusek M, Jiracek J and Vetvicka V: 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231. Oncol Rep 19: 1237-1244, 2008.
APA
Selicharova, I., Sanda, M., Mladkova, J., Ohri, S.S., Vashishta, A., Fusek, M. ... Vetvicka, V. (2008). 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231. Oncology Reports, 19, 1237-1244. https://doi.org/10.3892/or.19.5.1237
MLA
Selicharova, I., Sanda, M., Mladkova, J., Ohri, S. S., Vashishta, A., Fusek, M., Jiracek, J., Vetvicka, V."2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231". Oncology Reports 19.5 (2008): 1237-1244.
Chicago
Selicharova, I., Sanda, M., Mladkova, J., Ohri, S. S., Vashishta, A., Fusek, M., Jiracek, J., Vetvicka, V."2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231". Oncology Reports 19, no. 5 (2008): 1237-1244. https://doi.org/10.3892/or.19.5.1237
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