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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2008 Volume 19 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential

  • Authors:
    • Jin-Chul Heo
    • Minsik Son
    • Sang-Uk Woo
    • Mi-Ae Kweon
    • Eun Kyung Yoon
    • Hee Kyung Lee
    • Won-Sik Choi
    • Kang-Jin Cho
    • Sang-Han Lee

  • View Affiliations / Copyright

    Affiliations: Food and Bio-Industry Research Institute, Graduate School, Kyungpook National University, Daegu 702-701, Korea
  • Pages: 1399-1403
    |
    Published online on: June 1, 2008
       https://doi.org/10.3892/or.19.6.1399
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Abstract

The plant Geum japonicum Thunberg (GjT) has been used as a diuretic in traditional medicine. Herein, we report that the GjT extract blocks both the spread of human umbilical vein endothelial cells (HUVECs) on matrigel and the migration of B16 cells. We used various assays to test for cell attachment, spreading, wound healing and angiogenesis. A reverse transcription-polymerase chain reaction (RT-PCR) and a mitogen-activated protein kinase (MAPK) assay were also carried out for the mechanistic study of GjT. Our results showed that a fraction of methylene chloride fraction from GjT inhibited B16 cells during cell attachment and migration and suppressed tube formation in a dose-dependent manner. An RT-PCR analysis showed that the methylene chloride extract decreased the mRNA expression of CD44 and TIMP-2. A Western blot analysis of the phosphorylation of MAPK kinases (ERK, JNK and p38) showed that the GjT fraction increased the expression of phospho-JNK, suggesting that GjT has the potential to alleviate metastatic and angiogenic activity, via a phospho-JNK signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Heo J, Son M, Woo S, Kweon M, Yoon EK, Lee HK, Choi W, Cho K and Lee S: A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential. Oncol Rep 19: 1399-1403, 2008.
APA
Heo, J., Son, M., Woo, S., Kweon, M., Yoon, E.K., Lee, H.K. ... Lee, S. (2008). A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential. Oncology Reports, 19, 1399-1403. https://doi.org/10.3892/or.19.6.1399
MLA
Heo, J., Son, M., Woo, S., Kweon, M., Yoon, E. K., Lee, H. K., Choi, W., Cho, K., Lee, S."A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential". Oncology Reports 19.6 (2008): 1399-1403.
Chicago
Heo, J., Son, M., Woo, S., Kweon, M., Yoon, E. K., Lee, H. K., Choi, W., Cho, K., Lee, S."A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential". Oncology Reports 19, no. 6 (2008): 1399-1403. https://doi.org/10.3892/or.19.6.1399
Copy and paste a formatted citation
x
Spandidos Publications style
Heo J, Son M, Woo S, Kweon M, Yoon EK, Lee HK, Choi W, Cho K and Lee S: A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential. Oncol Rep 19: 1399-1403, 2008.
APA
Heo, J., Son, M., Woo, S., Kweon, M., Yoon, E.K., Lee, H.K. ... Lee, S. (2008). A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential. Oncology Reports, 19, 1399-1403. https://doi.org/10.3892/or.19.6.1399
MLA
Heo, J., Son, M., Woo, S., Kweon, M., Yoon, E. K., Lee, H. K., Choi, W., Cho, K., Lee, S."A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential". Oncology Reports 19.6 (2008): 1399-1403.
Chicago
Heo, J., Son, M., Woo, S., Kweon, M., Yoon, E. K., Lee, H. K., Choi, W., Cho, K., Lee, S."A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential". Oncology Reports 19, no. 6 (2008): 1399-1403. https://doi.org/10.3892/or.19.6.1399
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