Comparison of Epstein-Barr virus genotypes and clinicohistopathological features of nasopharyngeal carcinoma between Guilin, China and Fukuoka, Japan

Zhou,Yingqiong; Nabeshima,Kazuki; Koga,Kaori; Aoki,Mikiko; Hayashi,Hiroyuki; Hamasaki,Makoto; Iwasaki,Hiroshi

doi:10.3892/or.19.6.1413

June 2008 Volume 19 Issue 6

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June 2008 Volume 19 Issue 6

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Article

Comparison of Epstein-Barr virus genotypes and clinicohistopathological features of nasopharyngeal carcinoma between Guilin, China and Fukuoka, Japan

Authors:
- Yingqiong Zhou
- Kazuki Nabeshima
- Kaori Koga
- Mikiko Aoki
- Hiroyuki Hayashi
- Makoto Hamasaki
- Hiroshi Iwasaki
View Affiliations / Copyright

Affiliations: Department of Pathology, Fukuoka University Hospital and School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan
Pages: 1413-1420
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Published online on: June 1, 2008

https://doi.org/10.3892/or.19.6.1413
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Abstract

Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is endemic to Guilin, China, but not Fukuoka, Japan. To examine whether the NPC in these two cities are distinct in their association with EBV, we analyzed the histology and EBV genotypes in 163 NPC from Guilin, 52 NPC from Fukuoka and non-cancerous control nasopharyngeal tissues (n=22 each) by in situ hybridization and PCR. The proportion of EBV-positive NPC from Guilin (95%) was higher than that of Fukuoka (55%, p<0.001), and higher in NPC versus control tissues in Guilin (95 vs. 46%) and Fukuoka (55 vs. 32%). Histopathologically, non-keratinizing carcinoma and the undifferentiated subtype (NKC-U) were predominant in Guilin (84%), while the proportion of keratinizing squamous cell carcinoma (KSCC, 38%) was similar to NKC-U (42%) in Fukuoka. EBV-positivity was higher in NKC-U than KSCC in the two cities. EBV genotype A was highly prevalent in Guilin and Fukuoka. However, the BamHI f variant was predominant in Guilin (79%), whereas all the identified types were the F prototype in Fukuoka. The genetic structure and biological functions of the EBV strain associated with endemic NPC in Guilin were probably different from those of Fukuoka. The genetic differences between Guilin and Fukuoka may mirror the differences in histology and patient profiles.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparison of Epstein-Barr virus genotypes and clinicohistopathological features of nasopharyngeal carcinoma between Guilin, China and Fukuoka, Japan

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