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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2008 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2008 Volume 19 Issue 6

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Article

Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib

  • Authors:
    • Xiang Zhang
    • Hisashi Nagahara
    • Koshi Mimori
    • Hiroshi Inoue
    • Tetsuji Sawada
    • Masaichi Ohira
    • Kosei Hirakawa
    • Masaki Mori

  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Molecular Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu 874-0838, Japan
  • Pages: 1541-1544
    |
    Published online on: June 1, 2008
       https://doi.org/10.3892/or.19.6.1541
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Abstract

Somatic mutations of the epidermal growth factor receptor (EGFR) gene may predict the sensitivity of non-small cell lung cancers to gefitinib. In our previous study, we identified somatic mutations in the tyrosine kinase domain of the EGFR gene in 12.1% of colon cancer cases. Herein, we focus on whether the mutations are associated with the sensitivity of colon cancer to gefitinib. The E749K mutation in exon 19 and E762G and A767T mutations in exon 20 were introduced into the full-length EGFR coding sequence in a pBKCMV-hEGFR vector by site-directed mutagenesis and transfected into LS174T cells. The sensitivity to gefitinib was compared between the transfected LS174T and the parental cells by a cytotoxic assay. The LS174T cells with E749K were significantly (p<0.05) more responsive to gefitinib than the parental cells. On the other hand, LS174T cells with E762G or A767T were significantly (p<0.05) more resistant than the parental cells. In conclusion, detection of somatic mutations in the epidermal growth factor receptor may play an important role in predicting sensitivity to gefitinib in colon cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Nagahara H, Mimori K, Inoue H, Sawada T, Ohira M, Hirakawa K and Mori M: Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib. Oncol Rep 19: 1541-1544, 2008.
APA
Zhang, X., Nagahara, H., Mimori, K., Inoue, H., Sawada, T., Ohira, M. ... Mori, M. (2008). Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib. Oncology Reports, 19, 1541-1544. https://doi.org/10.3892/or.19.6.1541
MLA
Zhang, X., Nagahara, H., Mimori, K., Inoue, H., Sawada, T., Ohira, M., Hirakawa, K., Mori, M."Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib". Oncology Reports 19.6 (2008): 1541-1544.
Chicago
Zhang, X., Nagahara, H., Mimori, K., Inoue, H., Sawada, T., Ohira, M., Hirakawa, K., Mori, M."Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib". Oncology Reports 19, no. 6 (2008): 1541-1544. https://doi.org/10.3892/or.19.6.1541
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Nagahara H, Mimori K, Inoue H, Sawada T, Ohira M, Hirakawa K and Mori M: Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib. Oncol Rep 19: 1541-1544, 2008.
APA
Zhang, X., Nagahara, H., Mimori, K., Inoue, H., Sawada, T., Ohira, M. ... Mori, M. (2008). Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib. Oncology Reports, 19, 1541-1544. https://doi.org/10.3892/or.19.6.1541
MLA
Zhang, X., Nagahara, H., Mimori, K., Inoue, H., Sawada, T., Ohira, M., Hirakawa, K., Mori, M."Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib". Oncology Reports 19.6 (2008): 1541-1544.
Chicago
Zhang, X., Nagahara, H., Mimori, K., Inoue, H., Sawada, T., Ohira, M., Hirakawa, K., Mori, M."Mutations of epidermal growth factor receptor in colon cancer indicate susceptibility or resistance to gefitinib". Oncology Reports 19, no. 6 (2008): 1541-1544. https://doi.org/10.3892/or.19.6.1541
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