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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2008 Volume 19 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression

  • Authors:
    • Samantha Zongaro
    • Annalisa Verri
    • Elena Giulotto
    • Chiara Mondello

  • View Affiliations / Copyright

    Affiliations: Istituto di Genetica Molecolare, CNR, 27100 Pavia, Italy
  • Pages: 1605-1609
    |
    Published online on: June 1, 2008
       https://doi.org/10.3892/or.19.6.1605
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Abstract

Telomeres, the ends of eukaryotic chromosomes, have a variable length among individuals and cell types. While studies in telomerase-deficient mice and cells showed an inverse correlation between telomere length and radiosensitivity, it is less clear whether this remains true in telomerase-proficient cells. To gain insight into this topic, we studied radiosensitivity in three telomerase immortalized fibroblast clones derived from the same cell line and characterized by different telomere length. In two clones, cen3tel4 and cen3tel5, the mean terminal restriction fragment length was ≈13 and 10 kb, respectively and in the third clone, cen3pci16, it was ≈4 kb, which is lower than in senescent fibroblasts. To test radiosensitivity, we determined survival to γ-rays and the induction of chromosomal aberrations after irradiation. Neither the LD50, the γ-ray dose that reduces survival to 50%, nor the frequency of aberrations detected in the three cell lines showed an inverse correlation with telomere length. In particular, the cen3pci16 cells, which have very short telomeres, did not show a higher sensitivity to irradiation or a greater frequency of chromosomal abnormalities compared to the other two cell lines. Our results suggest that, in the presence of telomerase activity, short telomeres are stabilized and do not cause an increase in radiosensitivity.

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Copy and paste a formatted citation
Spandidos Publications style
Zongaro S, Verri A, Giulotto E and Mondello C: Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression. Oncol Rep 19: 1605-1609, 2008.
APA
Zongaro, S., Verri, A., Giulotto, E., & Mondello, C. (2008). Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression. Oncology Reports, 19, 1605-1609. https://doi.org/10.3892/or.19.6.1605
MLA
Zongaro, S., Verri, A., Giulotto, E., Mondello, C."Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression". Oncology Reports 19.6 (2008): 1605-1609.
Chicago
Zongaro, S., Verri, A., Giulotto, E., Mondello, C."Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression". Oncology Reports 19, no. 6 (2008): 1605-1609. https://doi.org/10.3892/or.19.6.1605
Copy and paste a formatted citation
x
Spandidos Publications style
Zongaro S, Verri A, Giulotto E and Mondello C: Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression. Oncol Rep 19: 1605-1609, 2008.
APA
Zongaro, S., Verri, A., Giulotto, E., & Mondello, C. (2008). Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression. Oncology Reports, 19, 1605-1609. https://doi.org/10.3892/or.19.6.1605
MLA
Zongaro, S., Verri, A., Giulotto, E., Mondello, C."Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression". Oncology Reports 19.6 (2008): 1605-1609.
Chicago
Zongaro, S., Verri, A., Giulotto, E., Mondello, C."Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression". Oncology Reports 19, no. 6 (2008): 1605-1609. https://doi.org/10.3892/or.19.6.1605
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