5-FLUOROURACIL COMBINED WITH THE PURE L-STEREOISOMER OF LEUKOVORIN CALCIUM TO TREAT ADVANCED COLON-CANCER PATIENTS - A PHASE-II STUDY

  • Authors:
    • C PORTA
    • M MORONI
    • G NASTASI
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/or.2.1.73
  • Pages: 73-76
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Abstract

A theoretical superiority of 5-fluorouracil (FUra) activity when combined with l-leucovorin (LV) might be postulated on the basis of a possible interference of the inactive d-stereoisomer of LV with the active l-form. We treated 47 patients by means of FUra (370 mg/m2/day) and l-LV (100 mg/m2/day), for 5 consecutive days, every 4 weeks. An objective response was observed in 12 patients (25.5%, 95% confidence interval: 12.5-38.5%), with 2 complete responses. As regards toxicity, 53.1% of the patients experienced mucositis, 51% diarrhea, 31.9% nausea and vomiting, 12.7% leukocytopenia, 8.5% cutaneous toxicity, 4.25% neurotoxicity, conjunctivitis and phlebitis. This regimen appears to be substantially superimposible to the classic FUra/d,l-LV combination. Therefore, the use of l-LV, in those countries where this compound is commercially available, should not be discouraged.

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January 1995
Volume 2 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
PORTA C, MORONI M and NASTASI G: 5-FLUOROURACIL COMBINED WITH THE PURE L-STEREOISOMER OF LEUKOVORIN CALCIUM TO TREAT ADVANCED COLON-CANCER PATIENTS - A PHASE-II STUDY. Oncol Rep 2: 73-76, 1995.
APA
PORTA, C., MORONI, M., & NASTASI, G. (1995). 5-FLUOROURACIL COMBINED WITH THE PURE L-STEREOISOMER OF LEUKOVORIN CALCIUM TO TREAT ADVANCED COLON-CANCER PATIENTS - A PHASE-II STUDY. Oncology Reports, 2, 73-76. https://doi.org/10.3892/or.2.1.73
MLA
PORTA, C., MORONI, M., NASTASI, G."5-FLUOROURACIL COMBINED WITH THE PURE L-STEREOISOMER OF LEUKOVORIN CALCIUM TO TREAT ADVANCED COLON-CANCER PATIENTS - A PHASE-II STUDY". Oncology Reports 2.1 (1995): 73-76.
Chicago
PORTA, C., MORONI, M., NASTASI, G."5-FLUOROURACIL COMBINED WITH THE PURE L-STEREOISOMER OF LEUKOVORIN CALCIUM TO TREAT ADVANCED COLON-CANCER PATIENTS - A PHASE-II STUDY". Oncology Reports 2, no. 1 (1995): 73-76. https://doi.org/10.3892/or.2.1.73