ONCOPROTEIN FOS ACTIVATION IN EPITHELIAL-CELLS INDUCES AN EPITHELIOMESENCHYMAL CONVERSION AND CHANGES THE RECEPTOR ENCODED BY THE FGFR-2 MESSENGER-RNA FROM K-SAM TO BEK
- Authors:
- Published online on: March 1, 1995 https://doi.org/10.3892/or.2.2.203
- Pages: 203-207
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
Activation of c-Fos, by using an inducible c-Fos estrogen receptor fusion protein, triggers the epitheliofibroblastoid cell conversion of mouse mammary epithelial cells. We show that this change in phenotype is accompanied by a definitive switch of the fibroblast growth factor receptor 2 from K-SAM to BEK. This splicing switch occurs a few hours after estrogen stimulation. Our data suggest that Fos proteins could be important in modulating the FGFR-2 splicing choice. Moreover, these observations reinforce previous evidence that the BEK/K-SAM choice is strictly tissue-specific: the K-SAM exon is expressed exclusively in epithelial cells, the BEK exon in cells of the fibroblastic type.
