ONCOPROTEIN FOS ACTIVATION IN EPITHELIAL-CELLS INDUCES AN EPITHELIOMESENCHYMAL CONVERSION AND CHANGES THE RECEPTOR ENCODED BY THE FGFR-2 MESSENGER-RNA FROM K-SAM TO BEK
- E SCOTET
- E REICHMANN
- R BREATHNACH
- E HOUSSAINT
Affiliations: INST BIOL,INSERM,U211,9 QUAI MONCOUSU,F-44035 NANTES 01,FRANCE. UNIV NANTES,FAC SCI & TECH,F-44035 NANTES,FRANCE. SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND.
- Published online on: March 1, 1995 https://doi.org/10.3892/or.2.2.203
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Activation of c-Fos, by using an inducible c-Fos estrogen receptor fusion protein, triggers the epitheliofibroblastoid cell conversion of mouse mammary epithelial cells. We show that this change in phenotype is accompanied by a definitive switch of the fibroblast growth factor receptor 2 from K-SAM to BEK. This splicing switch occurs a few hours after estrogen stimulation. Our data suggest that Fos proteins could be important in modulating the FGFR-2 splicing choice. Moreover, these observations reinforce previous evidence that the BEK/K-SAM choice is strictly tissue-specific: the K-SAM exon is expressed exclusively in epithelial cells, the BEK exon in cells of the fibroblastic type.