IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN AND PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN SALIVARY-GLAND TUMORS

WEN,SM; TSUJI,T; LI,XW; MIMURA,Y; SASAKI,K; SHINOZAKI,F

doi:10.3892/or.2.2.233

IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN AND PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN SALIVARY-GLAND TUMORS

Authors:
- SM WEN
- T TSUJI
- XW LI
- Y MIMURA
- K SASAKI
- F SHINOZAKI
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Affiliations: YAMAGUCHI UNIV,SCH MED,DEPT ORAL & MAXILLOFACIAL SURG,1144 KOGUSHI,UBE,YAMAGUCHI 755,JAPAN. CHINA MED UNIV,SCH MED,DEPT ORAL & MAXILLOFACIAL SURG,SHENYANG 110002,PEOPLES R CHINA. CHINA MED UNIV,SCH MED,DEPT ORAL PATHOL,SHENYANG 110002,PEOPLES R CHINA. YAMAGUCHI UNIV,SCH MED,DEPT PATHOL 2,UBE,YAMAGUCHI 755,JAPAN. IWATE MED UNIV,SCH MED,DEPT PATHOL 1,MORIOKA,IWATE 020,JAPAN.
Published online on: March 1, 1995 https://doi.org/10.3892/or.2.2.233
Pages: 233-236

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Abstract

The expression of p53 protein and PCNA was immunohistochemically examined in 161 cases of salivary gland tumors. The p53 protein was positive in 23.8% (24/101) of malignant salivary gland tumors, while only one case of 60 pleomorphic adenomas was positive. p53 protein was frequently detectable in salivary duct carcinoma (60%), basal cell adenocarcinoma (66.7%), acinic cell carcinoma (53.3%) and undifferentiated carcinoma (50%), but was rarely seen in adenoid cystic carcinoma (17.2%) and mucoepidermoid carcinoma (0%). p53 protein was more frequently detectable in PCNA positive cases than in negative cases (p=0.0074).