ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES

  • Authors:
    • Y MIZUSHIMA
    • T KASHII
    • M KOBAYASHI
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/or.2.2.277
  • Pages: 277-280
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Abstract

The association between gene alterations (K-ras, p53, N-myc) and drug resistance (CDDP, CBDCA, MMC, Epi-ADM) was examined in 29 human lung carcinoma cell lines using the in vitro MTT assay. There was no significant difference in the IC50 values of four drugs between K-ras or p53 gene alteration-positive and -negative groups. However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc amplification to all four drugs. This preliminary study suggests that K-ras or p53 gene alteration is probably not related to drug resistance, but N-myc might be.

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March 1995
Volume 2 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
MIZUSHIMA Y, KASHII T and KOBAYASHI M: ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES. Oncol Rep 2: 277-280, 1995
APA
MIZUSHIMA, Y., KASHII, T., & KOBAYASHI, M. (1995). ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES. Oncology Reports, 2, 277-280. https://doi.org/10.3892/or.2.2.277
MLA
MIZUSHIMA, Y., KASHII, T., KOBAYASHI, M."ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES". Oncology Reports 2.2 (1995): 277-280.
Chicago
MIZUSHIMA, Y., KASHII, T., KOBAYASHI, M."ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES". Oncology Reports 2, no. 2 (1995): 277-280. https://doi.org/10.3892/or.2.2.277