MORPHOLOGIC CHANGES OF DOXORUBICIN-SENSITIVE AND RESISTANT LOVO CELLS TREATED IN-VITRO BY CALCIUM CHANNELS BLOCKERS
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- Published online on: May 1, 1995 https://doi.org/10.3892/or.2.3.417
- Pages: 417-421
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Abstract
A morphological analysis by scanning electron microscopy (SEM) of the effect of two Ca++ channel blockers (verapamil and dilazep) on LoVo S (doxorubicin sensitive) and LoVo R (doxorubicin resistant) plated together with 3T3 in order to cause an experimental ground of metastasis was performed. Ca++ channel blockers have been previously tested alone and combined with doxorubicin. The increasing effect on the sensitivity of inherently antiblastic drug resistance and their possible role as antimetastatic agent according to the experiments of Tsuruo et al (Cancer Chemother Pharmacol 14: 30-33, 1985) is reported.
