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ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO

  • Authors:
    • M IMAMURA
    • T SEKI
    • K KUNIEDA
    • M WAKABAYASHI
    • K INOUE
    • Y OBIYA
    • K HARADA

  • View Affiliations

  • Published online on: July 1, 1995     https://doi.org/10.3892/or.2.4.509
  • Pages: 509-511
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We prepared hydroxyapatite (HAP) beads containing doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO), as a DOX and BSO-HAP complex. When the complex was implanted into mice bearing sarcoma 180 tumor, the antitumor effect of the complex was intensified 1.5-fold, as assessed using tumor volume, on day 27 as compared with that of a complex of DOX-HAP only. Therefore, we concluded that the antitumor effect of the DOX and BSO-HAP complex was increased through depletion of the intracellular radical scavenger glutathione (GSH) by released BSO and subsequently free radicals produced by released DOX.

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July 1995
Volume 2 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
IMAMURA M, SEKI T, KUNIEDA K, WAKABAYASHI M, INOUE K, OBIYA Y and HARADA K: ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO. Oncol Rep 2: 509-511, 1995
APA
IMAMURA, M., SEKI, T., KUNIEDA, K., WAKABAYASHI, M., INOUE, K., OBIYA, Y., & HARADA, K. (1995). ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO. Oncology Reports, 2, 509-511. https://doi.org/10.3892/or.2.4.509
MLA
IMAMURA, M., SEKI, T., KUNIEDA, K., WAKABAYASHI, M., INOUE, K., OBIYA, Y., HARADA, K."ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO". Oncology Reports 2.4 (1995): 509-511.
Chicago
IMAMURA, M., SEKI, T., KUNIEDA, K., WAKABAYASHI, M., INOUE, K., OBIYA, Y., HARADA, K."ANTITUMOR EFFECTS OF DOXORUBICIN HYDROCHLORIDE (DOX) AND BUTHIONINE SULFOXIMINE (BSO)-HYDROXYAPATITE (HAP) COMPLEX ON TRANSPLANTED TUMORS IN-VIVO". Oncology Reports 2, no. 4 (1995): 509-511. https://doi.org/10.3892/or.2.4.509