DELETION OF TP53 EXON-1 IN HUMAN EPITHELIAL OVARIAN-CANCER

  • Authors:
    • MA LANE
    • N ABDELLATIF
    • DA BAUNOCH
    • LM KAUFMAN
    • MD ADELSON
    • MT REECE
  • View Affiliations

  • Published online on: July 1, 1995     https://doi.org/10.3892/or.2.4.529
  • Pages: 529-536
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Abstract

In ovarian cancer, allelic loss within 17p 13.1-13.3, which contains the tumor suppressor TP53, occurs with a frequency of 66%, and mutations within conserved TP53 exons are reported in approximately 50% of cases. We examined DNA from 26 Stage III/IV ovarian carcinomas and 7 non-malignant ovaries by Southern blot hybridization and PCR for gene rearrangement or deletion within the,TP53 locus. Deletion specifically involving loss of the transcription-regulatory exon 1/intron 1 region on at least one allele was detected in 24/26 (92%) cases, and 0/7 noncancerous ovaries. Immunocytochemical analysis confirmed absence of expression of mutant p53 protein in those tumors where loss of the exon 1 region involved both alleles.

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July 1995
Volume 2 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
LANE M, ABDELLATIF N, BAUNOCH D, KAUFMAN L, ADELSON M and REECE M: DELETION OF TP53 EXON-1 IN HUMAN EPITHELIAL OVARIAN-CANCER. Oncol Rep 2: 529-536, 1995
APA
LANE, M., ABDELLATIF, N., BAUNOCH, D., KAUFMAN, L., ADELSON, M., & REECE, M. (1995). DELETION OF TP53 EXON-1 IN HUMAN EPITHELIAL OVARIAN-CANCER. Oncology Reports, 2, 529-536. https://doi.org/10.3892/or.2.4.529
MLA
LANE, M., ABDELLATIF, N., BAUNOCH, D., KAUFMAN, L., ADELSON, M., REECE, M."DELETION OF TP53 EXON-1 IN HUMAN EPITHELIAL OVARIAN-CANCER". Oncology Reports 2.4 (1995): 529-536.
Chicago
LANE, M., ABDELLATIF, N., BAUNOCH, D., KAUFMAN, L., ADELSON, M., REECE, M."DELETION OF TP53 EXON-1 IN HUMAN EPITHELIAL OVARIAN-CANCER". Oncology Reports 2, no. 4 (1995): 529-536. https://doi.org/10.3892/or.2.4.529