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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1995 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1995 Volume 2 Issue 4

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Article

PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA

  • Authors:
    • K MOTOMURA
    • H KOYAMA
    • S NOGUCHI
    • H INAJI

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 563-566
    |
    Published online on: July 1, 1995
       https://doi.org/10.3892/or.2.4.563
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Abstract

The presence of comedo carcinoma in the intraductal component is an important pathologic feature for predicting local recurrence after breast conserving treatment. Furthermore, the c-erbB-2 gene is frequently overexpressed in comedo carcinoma and it correlates well with gene amplification. This study revealed that 77.0% of the c-erbB-2 amplification positive tumors had intraductal lesions of the comedo type; while only 6.7% of the amplification negative tumors had comedo carcinoma (X(2)=106.6, p<0.0001). Accordingly, when c-erbB-2 amplification is detected in the invasive tumor, intraductal lesions which may co-exist in the tumor are likely to be comedo carcinoma. To predict the presence of comedo type intraductal carcinoma, c-erbB-2 gene amplification was analysed by means of polymerase chain reaction (PCR) from small samples of fine-needle aspiration biopsies. Breast tumors from ten patients were analysed and one had a 3.4-fold amplification of c-erbB-2 gene. The pathological appearance of this case was pure ductal carcinoma in situ with comedo carcinoma. The preoperative detection of c-erbB-2 gene amplification by PCR will be a useful means of selecting patients at high risk for local recurrence after breast conserving treatment.

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Copy and paste a formatted citation
Spandidos Publications style
MOTOMURA K, KOYAMA H, NOGUCHI S and INAJI H: PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA. Oncol Rep 2: 563-566, 1995.
APA
MOTOMURA, K., KOYAMA, H., NOGUCHI, S., & INAJI, H. (1995). PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA. Oncology Reports, 2, 563-566. https://doi.org/10.3892/or.2.4.563
MLA
MOTOMURA, K., KOYAMA, H., NOGUCHI, S., INAJI, H."PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA". Oncology Reports 2.4 (1995): 563-566.
Chicago
MOTOMURA, K., KOYAMA, H., NOGUCHI, S., INAJI, H."PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA". Oncology Reports 2, no. 4 (1995): 563-566. https://doi.org/10.3892/or.2.4.563
Copy and paste a formatted citation
x
Spandidos Publications style
MOTOMURA K, KOYAMA H, NOGUCHI S and INAJI H: PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA. Oncol Rep 2: 563-566, 1995.
APA
MOTOMURA, K., KOYAMA, H., NOGUCHI, S., & INAJI, H. (1995). PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA. Oncology Reports, 2, 563-566. https://doi.org/10.3892/or.2.4.563
MLA
MOTOMURA, K., KOYAMA, H., NOGUCHI, S., INAJI, H."PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA". Oncology Reports 2.4 (1995): 563-566.
Chicago
MOTOMURA, K., KOYAMA, H., NOGUCHI, S., INAJI, H."PREOPERATIVE DETECTION OF C-ERBB-2 GENE AMPLIFICATION AS A PREDICTOR OF LOCAL RECURRENCE AFTER CONSERVATIVE TREATMENT FOR BREAST-CARCINOMA". Oncology Reports 2, no. 4 (1995): 563-566. https://doi.org/10.3892/or.2.4.563
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