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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1995 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1995 Volume 2 Issue 4

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Article

ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL

  • Authors:
    • A RICCARDI
    • M GIORDANO
    • S BRUGNATELLI
    • G UCCI
    • M DANOVA
    • O MORA
    • S FAVA
    • E ASCARI

  • View Affiliations / Copyright

    Affiliations: UNIV PAVIA,I-27100 PAVIA,ITALY. OSPED S ANNA COMO,COMO,ITALY. OSPED LEGNANO,LEGNARO,ITALY.
  • Pages: 577-582
    |
    Published online on: July 1, 1995
       https://doi.org/10.3892/or.2.4.577
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Abstract

A moderate increase in the dose of anthracycline could be feasible and of clinical benefit in advanced breast cancer. Between April 1991 and April 1994, 69 consecutive patients with recurrent or metastatic breast cancer were randomly treated with two regimens, including different dosages of epirubicin (75 versus 100 mg/m(2)) associated with the same dosage (600 mg/m(2)) of cyclophosphamide and 5-fluoruracil (75-FEC vs 100-FEC). Patients were planned to receive 6 courses at 21 day-intervals. Thirty-six patients received the 75-FEC regimen and 33 received the 100-FEC regimen. The two groups were comparable for age, menopausal status, disease-free interval, previous therapy, performance status and sites of disease: Over the whole study, the 100-FEC regimen has allowed a 18% actual increase in the epirubicin dosage over the 75-FEC regimen. Overall response rate was 56% for the 100-FEC and 51% for the 75-FEC, with the 100-FEC inducing some more complete responses than the 75-FEC (38% vs 23%). Survival (but not time to progression) tended to be longer with the 100- than with the 75-FEC (median: 20 vs 13 mos, p<0.09). Nonhematologic side effects Were similar. Hematologic toxicity was slightly higher with 100- than with 75-FEC, with granulocyte colony stimulating factors used to recycle in the scheduled time in the 15 and 4% of courses, respectively.

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Copy and paste a formatted citation
Spandidos Publications style
RICCARDI A, GIORDANO M, BRUGNATELLI S, UCCI G, DANOVA M, MORA O, FAVA S and ASCARI E: ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL. Oncol Rep 2: 577-582, 1995.
APA
RICCARDI, A., GIORDANO, M., BRUGNATELLI, S., UCCI, G., DANOVA, M., MORA, O. ... ASCARI, E. (1995). ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL. Oncology Reports, 2, 577-582. https://doi.org/10.3892/or.2.4.577
MLA
RICCARDI, A., GIORDANO, M., BRUGNATELLI, S., UCCI, G., DANOVA, M., MORA, O., FAVA, S., ASCARI, E."ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL". Oncology Reports 2.4 (1995): 577-582.
Chicago
RICCARDI, A., GIORDANO, M., BRUGNATELLI, S., UCCI, G., DANOVA, M., MORA, O., FAVA, S., ASCARI, E."ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL". Oncology Reports 2, no. 4 (1995): 577-582. https://doi.org/10.3892/or.2.4.577
Copy and paste a formatted citation
x
Spandidos Publications style
RICCARDI A, GIORDANO M, BRUGNATELLI S, UCCI G, DANOVA M, MORA O, FAVA S and ASCARI E: ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL. Oncol Rep 2: 577-582, 1995.
APA
RICCARDI, A., GIORDANO, M., BRUGNATELLI, S., UCCI, G., DANOVA, M., MORA, O. ... ASCARI, E. (1995). ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL. Oncology Reports, 2, 577-582. https://doi.org/10.3892/or.2.4.577
MLA
RICCARDI, A., GIORDANO, M., BRUGNATELLI, S., UCCI, G., DANOVA, M., MORA, O., FAVA, S., ASCARI, E."ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL". Oncology Reports 2.4 (1995): 577-582.
Chicago
RICCARDI, A., GIORDANO, M., BRUGNATELLI, S., UCCI, G., DANOVA, M., MORA, O., FAVA, S., ASCARI, E."ADVANCED BREAST-CANCER - A RANDOMIZED STUDY OF DIFFERENT DOSES OF EPIRUBICIN ASSOCIATED WITH FIXED DOSES OF CYCLOPHOSPHAMIDE AND 5-FLUOROURACIL". Oncology Reports 2, no. 4 (1995): 577-582. https://doi.org/10.3892/or.2.4.577
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