EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER

  • Authors:
    • RE HARRIS
    • KK NAMBOODIRI
    • WB FARRAR
  • View Affiliations

  • Published online on: July 1, 1995     https://doi.org/10.3892/or.2.4.591
  • Pages: 591-592
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Abstract

The association of nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk was examined in a case-control study of 303 breast cancer patients and 906 population control subjects. Breast cancer cases reported a significantly lower frequency of regular NSAID use than controls (19.1% versus 26.8%, p<0.01) and the resulting odds ratio adjusted for other risk factors was significantly less than 1 (OR=0.65, 95% CI=0.5-0.9, p<0.01). Regular intake of NSAIDs (greater than or equal to 3 times per week for greater than or equal to 6 months) was associated with a 36% reduction in the risk of breast cancer (OR=0.64, 95% CI=0.4-0.9, p<0.01). Greater use (greater than or equal to 7 times per week for greater than or equal to 5 years) resulted in a 40% risk reduction (OR=0.60, 95% CI=0.4-0.9, p<0.05). The observed effects of non-prescription and prescription NSAIDs were similar, although sample sizes were small for individual compounds. These results suggest that NSAIDs may have chemopreventive potential against the development of breast cancer.

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July 1995
Volume 2 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
HARRIS R, NAMBOODIRI K and FARRAR W: EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER. Oncol Rep 2: 591-592, 1995
APA
HARRIS, R., NAMBOODIRI, K., & FARRAR, W. (1995). EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER. Oncology Reports, 2, 591-592. https://doi.org/10.3892/or.2.4.591
MLA
HARRIS, R., NAMBOODIRI, K., FARRAR, W."EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER". Oncology Reports 2.4 (1995): 591-592.
Chicago
HARRIS, R., NAMBOODIRI, K., FARRAR, W."EPIDEMIOLOGIC-STUDY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND BREAST-CANCER". Oncology Reports 2, no. 4 (1995): 591-592. https://doi.org/10.3892/or.2.4.591