P-GLYCOPROTEIN EXPRESSION IN CHRONIC LYMPHOCYTIC-LEUKEMIA - ASSOCIATION WITH CHEMOTHERAPY

  • Authors:
    • I CHINYEE
    • LC WRIGHT
    • E BOYLE
    • M KEENEY
    • RC LOHMANN
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/or.2.5.833
  • Pages: 833-837
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

P-glycoprotein (PgP), a transmembrane protein, has been associated with multiple drug resistance. We examined 42 patients with chronic lymphocytic leukemia immunohistochemically using the monoclonal antibody JSB-1 to determine the prevalence of PgP expression and its relationship with chemotherapy exposure. Of the 42 patients, 31 (74%) had detectable PgP. No relationship was found between PgP expression, patient age, duration of disease or stage. Moderate and strong intensity staining was found in 22% of untreated patients versus 56% patients treated with chemotherapy (p<0.05). Temporal fluctuations in P-glycoprotein staining intensity was seen in 6 of 7 cases which paralleled the initiation or withdrawal of the therapy.

Related Articles

Journal Cover

September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
CHINYEE I, WRIGHT L, BOYLE E, KEENEY M and LOHMANN R: P-GLYCOPROTEIN EXPRESSION IN CHRONIC LYMPHOCYTIC-LEUKEMIA - ASSOCIATION WITH CHEMOTHERAPY. Oncol Rep 2: 833-837, 1995.
APA
CHINYEE, I., WRIGHT, L., BOYLE, E., KEENEY, M., & LOHMANN, R. (1995). P-GLYCOPROTEIN EXPRESSION IN CHRONIC LYMPHOCYTIC-LEUKEMIA - ASSOCIATION WITH CHEMOTHERAPY. Oncology Reports, 2, 833-837. https://doi.org/10.3892/or.2.5.833
MLA
CHINYEE, I., WRIGHT, L., BOYLE, E., KEENEY, M., LOHMANN, R."P-GLYCOPROTEIN EXPRESSION IN CHRONIC LYMPHOCYTIC-LEUKEMIA - ASSOCIATION WITH CHEMOTHERAPY". Oncology Reports 2.5 (1995): 833-837.
Chicago
CHINYEE, I., WRIGHT, L., BOYLE, E., KEENEY, M., LOHMANN, R."P-GLYCOPROTEIN EXPRESSION IN CHRONIC LYMPHOCYTIC-LEUKEMIA - ASSOCIATION WITH CHEMOTHERAPY". Oncology Reports 2, no. 5 (1995): 833-837. https://doi.org/10.3892/or.2.5.833