ADRIAMYCIN AND CISPLATIN INDUCE APOPTOSIS IN 2 LINES OF HUMAN GASTRIC-CANCER CELLS (MKN-28 AND HSC-39)

  • Authors:
    • M IKEGUCHI
    • K KATANO
    • S TATEBE
    • A OKA
    • S TSUJITANI
    • M MAETA
    • N KAIBARA
    • H HORIKAWA
    • H ITO
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/or.2.6.1027
  • Pages: 1027-1032
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Abstract

Many anticancer agents induce an active process that leads to cell death, known as, apoptosis, in sensitive tumor cells. The fragmentation of DNA, an indicator of apoptosis, was analyzed in two different lines of human gastric cancer cells (HSC-39 and MKN-28) that had been exposed to adriamycin and cisplatin. The fragmentation of DNA was detected in HSC-39 cells (signet ring cell gastric carcinoma) after a 1-h incubation with 0.18 mu M and after a 6-h incubation with 0.09 mu M adriamycin, as well as after a 1-h incubation with 1.67 mu M cisplatin. However, in MKN-28 cells (moderately differentiated gastric adenocarcinoma), the fragmentation of DNA was not detected after a 6-h incubation with 0.18 mu M adriamycin or a 6-h incubation with 3.33 mu M cisplatin. The results suggest that signet ring cell gastric carcinoma is more sensitive to adriamycin and to cisplatin than moderately differentiated gastric adenocarcinoma.

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November 1995
Volume 2 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
IKEGUCHI M, KATANO K, TATEBE S, OKA A, TSUJITANI S, MAETA M, KAIBARA N, HORIKAWA H and ITO H: ADRIAMYCIN AND CISPLATIN INDUCE APOPTOSIS IN 2 LINES OF HUMAN GASTRIC-CANCER CELLS (MKN-28 AND HSC-39). Oncol Rep 2: 1027-1032, 1995
APA
IKEGUCHI, M., KATANO, K., TATEBE, S., OKA, A., TSUJITANI, S., MAETA, M. ... ITO, H. (1995). ADRIAMYCIN AND CISPLATIN INDUCE APOPTOSIS IN 2 LINES OF HUMAN GASTRIC-CANCER CELLS (MKN-28 AND HSC-39). Oncology Reports, 2, 1027-1032. https://doi.org/10.3892/or.2.6.1027
MLA
IKEGUCHI, M., KATANO, K., TATEBE, S., OKA, A., TSUJITANI, S., MAETA, M., KAIBARA, N., HORIKAWA, H., ITO, H."ADRIAMYCIN AND CISPLATIN INDUCE APOPTOSIS IN 2 LINES OF HUMAN GASTRIC-CANCER CELLS (MKN-28 AND HSC-39)". Oncology Reports 2.6 (1995): 1027-1032.
Chicago
IKEGUCHI, M., KATANO, K., TATEBE, S., OKA, A., TSUJITANI, S., MAETA, M., KAIBARA, N., HORIKAWA, H., ITO, H."ADRIAMYCIN AND CISPLATIN INDUCE APOPTOSIS IN 2 LINES OF HUMAN GASTRIC-CANCER CELLS (MKN-28 AND HSC-39)". Oncology Reports 2, no. 6 (1995): 1027-1032. https://doi.org/10.3892/or.2.6.1027