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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1995 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 2 Issue 6

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Article

ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY

  • Authors:
    • S CASCINU
    • E DELFERRO
    • C GRIANTI
    • A FEDELI
    • G CATALANO

  • View Affiliations / Copyright

    Affiliations: OSPED RIUNITI PESARO,ANAL LAB,I-61100 PESARO,ITALY.
  • Pages: 1033-1035
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/or.2.6.1033
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Abstract

Multidrug resistance, a major factor in the resistance to drugs, can be reversed by cyclosporin A. It is generally given by intravenous route. The aim of the present study was to assess the possibility of achieving useful plasma levels, giving cyclosporin A orally in advanced colorectal cancer patients treated with 4-epidoxorubicin. Cyclosporin A was given orally twice a day, for four days. The starting study dose was 5 mg/kg. Dose in cohorts of 3 patients was escalated to 10, 15, 20, 30, 40 mg/kg if the previous dose was not able to determine the target blood level (2,000 ng/ml). Cyclosporin A blood levels were analyzed by a specific fluorescence polarization immunoassay method (TDx; Abbot Laboratoires, North Chigaco, IL). 4-epidoxorubicin was given at a fixed dose of 75 mg/m(2), every 3 weeks. None of the dose levels of cyclosporin A given orally produced the target blood level. Only two patients, receiving cyclosporin at a dose of 30 mg/kg, and two after a CsA dose of 40 mg/kg, presented blood levels higher than 1,000 ng/ml, but however, lower than 1,500 ng/ml. In conclusion, the oral route of administration of cyclosporin does not seem recommendable in order to reverse multidrug resistance because it is not able to produce sufficient plasma levels.

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Copy and paste a formatted citation
Spandidos Publications style
CASCINU S, DELFERRO E, GRIANTI C, FEDELI A and CATALANO G: ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY. Oncol Rep 2: 1033-1035, 1995.
APA
CASCINU, S., DELFERRO, E., GRIANTI, C., FEDELI, A., & CATALANO, G. (1995). ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY. Oncology Reports, 2, 1033-1035. https://doi.org/10.3892/or.2.6.1033
MLA
CASCINU, S., DELFERRO, E., GRIANTI, C., FEDELI, A., CATALANO, G."ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY". Oncology Reports 2.6 (1995): 1033-1035.
Chicago
CASCINU, S., DELFERRO, E., GRIANTI, C., FEDELI, A., CATALANO, G."ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY". Oncology Reports 2, no. 6 (1995): 1033-1035. https://doi.org/10.3892/or.2.6.1033
Copy and paste a formatted citation
x
Spandidos Publications style
CASCINU S, DELFERRO E, GRIANTI C, FEDELI A and CATALANO G: ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY. Oncol Rep 2: 1033-1035, 1995.
APA
CASCINU, S., DELFERRO, E., GRIANTI, C., FEDELI, A., & CATALANO, G. (1995). ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY. Oncology Reports, 2, 1033-1035. https://doi.org/10.3892/or.2.6.1033
MLA
CASCINU, S., DELFERRO, E., GRIANTI, C., FEDELI, A., CATALANO, G."ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY". Oncology Reports 2.6 (1995): 1033-1035.
Chicago
CASCINU, S., DELFERRO, E., GRIANTI, C., FEDELI, A., CATALANO, G."ORAL ESCALATING DOSE OF CYCLOSPORINE-A COMBINED WITH 4-EPIDOXORUBICIN IN ADVANCED COLORECTAL-CANCER - A PHASE-I STUDY". Oncology Reports 2, no. 6 (1995): 1033-1035. https://doi.org/10.3892/or.2.6.1033
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