HUMAN PAPILLOMAVIRUS TYPE-16 DNA INTEGRATION IN NUCLEAR MATRIX AND CHROMOSOME SCAFFOLD ASSOCIATED DNA IN A CERVICAL-CARCINOMA CELL-LINE
- YF YAM
- EC CHEW
- L YANG
- SB CHENGCHEW
- MX DING
Affiliations: CHINESE UNIV HONG KONG,DEPT ANAT,SHA TIN,HONG KONG. CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHA TIN,HONG KONG. BEIJING UNIV,DEPT CELL BIOL,BEIJING,PEOPLES R CHINA.
- Published online on: November 1, 1995 https://doi.org/10.3892/or.2.6.1093
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MARs (matrix attachment region) and SARs (scaffold attachment region) are fragments of DNA that associated with nuclear matrix and chromosome scaffold even after extensive removal of most of the nuclear proteins and chromatin. The present study showed the association of human papillomavirus type 16 DNA with these fragments by polymerase chain reaction in a cervical carcinoma cell line, CC3/CUHK3. This finding proposed an alternative evidence for the elevated transcription rate of the viral genome in transformed cells as nuclear matrix has been proposed to be sites of DNA replication and transcription.