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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1995 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 2 Issue 6

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Article

GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA

  • Authors:
    • SL LAI
    • JG BATSAKIS
    • NG ORDONEZ
    • MA LUNA
    • H GOEPFERT
    • AK EL-NAGGAR

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEAD & NECK SURG,HOUSTON,TX 77030.
  • Pages: 1115-1120
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/or.2.6.1115
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Abstract

p53 is the most frequently altered suppressor gene in human cancers. The genotypic and corresponding phenotypic abnormalities of this gene in head and neck squamous cell carcinoma (HNSCC) remain undefined. We analyzed the loss of heterozygosity (LOH) by restriction fragment length polymorphism (RFLP) at three polymorphic loci in the p53 gene and performed immunohistochemistry (MC) for its protein on paraffin-embedded tumor tissue from 20 previously sequenced tumor specimens. LOH was noted at one or more of the three polymorphic sites within the p53 gene in 12 (67%) of the 18 informative samples. Concordance between LOH and mutations was observed in 14 (78%) cases. Twelve (60%) tumors with point mutations were immunohistochemically reactive to p53 antibody and two (10%) lacked both genetic and immunohistochemical alterations. In six tumors (30%) contradictory results between immunohistochemistry and molecular analysis were observed. Our data indicate that: (i) simultaneous deletion and mutation of both p53 alleles was observed in the majority of head and neck squamous carcinomas and implicate this gene in the oncogenesis of these neoplasms, (ii) p53 immunohistochemical analysis may not fully account for the different molecular alterations of this gene, and (iii) no correlation between p53 abnormalities and clinicopathologic or DNA content characteristics of HNSCC was found.

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Copy and paste a formatted citation
Spandidos Publications style
LAI S, BATSAKIS J, ORDONEZ N, LUNA M, GOEPFERT H and EL-NAGGAR A: GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA. Oncol Rep 2: 1115-1120, 1995.
APA
LAI, S., BATSAKIS, J., ORDONEZ, N., LUNA, M., GOEPFERT, H., & EL-NAGGAR, A. (1995). GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA. Oncology Reports, 2, 1115-1120. https://doi.org/10.3892/or.2.6.1115
MLA
LAI, S., BATSAKIS, J., ORDONEZ, N., LUNA, M., GOEPFERT, H., EL-NAGGAR, A."GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA". Oncology Reports 2.6 (1995): 1115-1120.
Chicago
LAI, S., BATSAKIS, J., ORDONEZ, N., LUNA, M., GOEPFERT, H., EL-NAGGAR, A."GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA". Oncology Reports 2, no. 6 (1995): 1115-1120. https://doi.org/10.3892/or.2.6.1115
Copy and paste a formatted citation
x
Spandidos Publications style
LAI S, BATSAKIS J, ORDONEZ N, LUNA M, GOEPFERT H and EL-NAGGAR A: GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA. Oncol Rep 2: 1115-1120, 1995.
APA
LAI, S., BATSAKIS, J., ORDONEZ, N., LUNA, M., GOEPFERT, H., & EL-NAGGAR, A. (1995). GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA. Oncology Reports, 2, 1115-1120. https://doi.org/10.3892/or.2.6.1115
MLA
LAI, S., BATSAKIS, J., ORDONEZ, N., LUNA, M., GOEPFERT, H., EL-NAGGAR, A."GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA". Oncology Reports 2.6 (1995): 1115-1120.
Chicago
LAI, S., BATSAKIS, J., ORDONEZ, N., LUNA, M., GOEPFERT, H., EL-NAGGAR, A."GENOTYPIC AND PHENOTYPIC ALTERATIONS OF P53 IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA". Oncology Reports 2, no. 6 (1995): 1115-1120. https://doi.org/10.3892/or.2.6.1115
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