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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1995 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 1995 Volume 2 Issue 6

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Article

A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER

  • Authors:
    • HL PARNES
    • N TAIT
    • B CONLEY
    • D VANECHO
  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 1131-1134
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/or.2.6.1131
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Abstract

CPT-11 is a topoisomerase I inhibitor with activity against colorectal cancer. This study was designed to explore the potential for combining CPT-11 with fluorouracil and leucovorin. 5-FU (500 mg/m(2)) and leucovorin (500 mg/m(2)) were administered for 4 consecutive weeks and CPT-11 was given on weeks 1 and 4 of each 6 week cycle. The starting dose of CPT-11 was 25 mg/m(2) and the dosage was escalated by increments of 25 mg/m(2) in cohorts of 3 patients. Nine patients were treated on study. Grade 4 diarrhea was the dose limiting toxicity at 50 mg/m(2). Alternative strategies to combine CPT-11 with 5-FU and leucovorin are being explored.

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Copy and paste a formatted citation
Spandidos Publications style
PARNES H, TAIT N, CONLEY B and VANECHO D: A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER. Oncol Rep 2: 1131-1134, 1995.
APA
PARNES, H., TAIT, N., CONLEY, B., & VANECHO, D. (1995). A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER. Oncology Reports, 2, 1131-1134. https://doi.org/10.3892/or.2.6.1131
MLA
PARNES, H., TAIT, N., CONLEY, B., VANECHO, D."A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER". Oncology Reports 2.6 (1995): 1131-1134.
Chicago
PARNES, H., TAIT, N., CONLEY, B., VANECHO, D."A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER". Oncology Reports 2, no. 6 (1995): 1131-1134. https://doi.org/10.3892/or.2.6.1131
Copy and paste a formatted citation
x
Spandidos Publications style
PARNES H, TAIT N, CONLEY B and VANECHO D: A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER. Oncol Rep 2: 1131-1134, 1995.
APA
PARNES, H., TAIT, N., CONLEY, B., & VANECHO, D. (1995). A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER. Oncology Reports, 2, 1131-1134. https://doi.org/10.3892/or.2.6.1131
MLA
PARNES, H., TAIT, N., CONLEY, B., VANECHO, D."A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER". Oncology Reports 2.6 (1995): 1131-1134.
Chicago
PARNES, H., TAIT, N., CONLEY, B., VANECHO, D."A PHASE-I STUDY OF CPT-11, WEEKLY BOLUS 5-FU AND LEUCOVORIN IN PATIENTS WITH METASTATIC CANCER". Oncology Reports 2, no. 6 (1995): 1131-1134. https://doi.org/10.3892/or.2.6.1131
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