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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2008 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2008 Volume 20 Issue 1

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Article

Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo

  • Authors:
    • Feng Wang
    • Lin Chen
    • Zhen-Biao Mao
    • Jian-Guo Shao
    • Chang Tan
    • Wei-Da Huang

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Affiliated Hospital of Nantong University, Jiangsu 226001, P.R. China
  • Pages: 135-139
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/or.20.1.135
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Abstract

RNA interference (RNAi) is an evolutionarily conserved process of gene silencing in multiple organisms, which has become a powerful tool for investigating gene function by reverse genetics. Herein, we constructed a short hairpin RNA (shRNA) lentiviral expression vector targeting a proliferation-inducing ligand (APRIL) gene in the CFPAC-1 cell (a type of cell strain of human pancreatic cancer) in order to observe the inhibitory effect of APRIL gene's shRNA on the growth of the CFPAC-1 cell in vitro and in vivo. The results showed that lentivirus-mediated RNAi effectively inhibited the expression of APRIL mRNA and protein in CFPAC-1 cells. Moreover, it can inhibit the growth of pancreatic cancer cells in vitro and in vivo. Our study indicates that lentivirus-mediated gene therapy is an attractive strategy in the treatment of pancreatic cancer and justifies the use of lentivirus in cancer gene therapy studies.

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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Chen L, Mao Z, Shao J, Tan C and Huang W: Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo. Oncol Rep 20: 135-139, 2008.
APA
Wang, F., Chen, L., Mao, Z., Shao, J., Tan, C., & Huang, W. (2008). Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo. Oncology Reports, 20, 135-139. https://doi.org/10.3892/or.20.1.135
MLA
Wang, F., Chen, L., Mao, Z., Shao, J., Tan, C., Huang, W."Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo". Oncology Reports 20.1 (2008): 135-139.
Chicago
Wang, F., Chen, L., Mao, Z., Shao, J., Tan, C., Huang, W."Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo". Oncology Reports 20, no. 1 (2008): 135-139. https://doi.org/10.3892/or.20.1.135
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Chen L, Mao Z, Shao J, Tan C and Huang W: Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo. Oncol Rep 20: 135-139, 2008.
APA
Wang, F., Chen, L., Mao, Z., Shao, J., Tan, C., & Huang, W. (2008). Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo. Oncology Reports, 20, 135-139. https://doi.org/10.3892/or.20.1.135
MLA
Wang, F., Chen, L., Mao, Z., Shao, J., Tan, C., Huang, W."Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo". Oncology Reports 20.1 (2008): 135-139.
Chicago
Wang, F., Chen, L., Mao, Z., Shao, J., Tan, C., Huang, W."Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo". Oncology Reports 20, no. 1 (2008): 135-139. https://doi.org/10.3892/or.20.1.135
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