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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2008 Volume 20 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Differential expression of Wnt13 isoforms during leukemic cell differentiation

  • Authors:
    • Rodica Petruta Bunaciu
    • Tao Tang
    • Catherine D. Mao

  • View Affiliations / Copyright

    Affiliations: Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506, USA
  • Pages: 195-201
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/or.20.1.195
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Abstract

Wnt proteins control cell fate and differentiation during development. Alterations of the Wnt/β-catenin signaling pathway and changes in wnt gene expression are clearly associated with leukemia. The expression of human wnt13/wnt2b is complex as it involves alternative promoters and RNA splicing giving rise to Wnt13A, -B and -C mRNA isoforms, which encode proteins with different intracellular localizations and functions. We investigated the expression of the human wnt13 in relation to leukemic cell differentiation. Differentiated endothelial cells expressed the highest levels of Wnt13 mRNA isoforms among various endothelial and leukemic cell lines. The differentiation of U937 cells towards monocyte/macrophages resulted in an increase of Wnt13B and -C mRNAs while Wnt13A mRNAs were decreased. The differentiation of K562 cells towards megakaryocytes was accompanied with the up-regulation of all Wnt13 mRNA isoforms. In the two differentiation systems, Wnt13B and -C expression correlated with the expression of the MAF-B transcription factor. Our data demonstrate the differential regulation of wnt13 promoters and pinpoint a Wnt13 isoform switch during differentiation of the leukemic U937 cells towards the monocyte/macrophage lineage, thereby suggesting new players in this process.

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Copy and paste a formatted citation
Spandidos Publications style
Bunaciu RP, Tang T and Mao CD: Differential expression of Wnt13 isoforms during leukemic cell differentiation. Oncol Rep 20: 195-201, 2008.
APA
Bunaciu, R.P., Tang, T., & Mao, C.D. (2008). Differential expression of Wnt13 isoforms during leukemic cell differentiation. Oncology Reports, 20, 195-201. https://doi.org/10.3892/or.20.1.195
MLA
Bunaciu, R. P., Tang, T., Mao, C. D."Differential expression of Wnt13 isoforms during leukemic cell differentiation". Oncology Reports 20.1 (2008): 195-201.
Chicago
Bunaciu, R. P., Tang, T., Mao, C. D."Differential expression of Wnt13 isoforms during leukemic cell differentiation". Oncology Reports 20, no. 1 (2008): 195-201. https://doi.org/10.3892/or.20.1.195
Copy and paste a formatted citation
x
Spandidos Publications style
Bunaciu RP, Tang T and Mao CD: Differential expression of Wnt13 isoforms during leukemic cell differentiation. Oncol Rep 20: 195-201, 2008.
APA
Bunaciu, R.P., Tang, T., & Mao, C.D. (2008). Differential expression of Wnt13 isoforms during leukemic cell differentiation. Oncology Reports, 20, 195-201. https://doi.org/10.3892/or.20.1.195
MLA
Bunaciu, R. P., Tang, T., Mao, C. D."Differential expression of Wnt13 isoforms during leukemic cell differentiation". Oncology Reports 20.1 (2008): 195-201.
Chicago
Bunaciu, R. P., Tang, T., Mao, C. D."Differential expression of Wnt13 isoforms during leukemic cell differentiation". Oncology Reports 20, no. 1 (2008): 195-201. https://doi.org/10.3892/or.20.1.195
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