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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2008 Volume 20 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome

  • Authors:
    • Hasmik Mkrtchyan
    • Seda Ghazaryan
    • Gayane Avetisyan
    • Anna Hovhannisyan
    • Laura Muradyan
    • Smbat Daghbashyan
    • Constanze Karst
    • Madeleine Gross
    • Sophie Hinreiner
    • Rouben Aroutiounian
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Institute of Human Genetics and Anthropology, D-07743 Jena, Germany. hasmik.mkrtchyan@mti.uni-jena.de
  • Pages: 99-104
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/or.20.1.99
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Abstract

The fusion gene BCR/ABL arises in connection with a complex translocation event in 2-10% of cases with chronic myeloid leukemia (CML). Due to causative treatment with Imatinib most cases with variant rearrangements show no specific prognostic significance, though the events of therapy resistance remain to be studied. Herein we report on three CML cases with complex chromosomal aberrations not observed before, involving chromosomal regions such as 1p32, 2q11 and 6q12. Additionally we report on one case with the rare translocation t(3;8)(p22;q22) along with the classic Philadelphia (Ph) chromosome. In two cases, two different breakpoints on chromosome 22 were found. Moreover, in one of them two breakpoints on chromosome 9 were observed. The following chromosomal studies, during therapy by Imatinib, have revealed different cytogenetic responses.

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Copy and paste a formatted citation
Spandidos Publications style
Mkrtchyan H, Ghazaryan S, Avetisyan G, Hovhannisyan A, Muradyan L, Daghbashyan S, Karst C, Gross M, Hinreiner S, Aroutiounian R, Aroutiounian R, et al: Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome. Oncol Rep 20: 99-104, 2008.
APA
Mkrtchyan, H., Ghazaryan, S., Avetisyan, G., Hovhannisyan, A., Muradyan, L., Daghbashyan, S. ... Liehr, T. (2008). Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome. Oncology Reports, 20, 99-104. https://doi.org/10.3892/or.20.1.99
MLA
Mkrtchyan, H., Ghazaryan, S., Avetisyan, G., Hovhannisyan, A., Muradyan, L., Daghbashyan, S., Karst, C., Gross, M., Hinreiner, S., Aroutiounian, R., Liehr, T."Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome". Oncology Reports 20.1 (2008): 99-104.
Chicago
Mkrtchyan, H., Ghazaryan, S., Avetisyan, G., Hovhannisyan, A., Muradyan, L., Daghbashyan, S., Karst, C., Gross, M., Hinreiner, S., Aroutiounian, R., Liehr, T."Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome". Oncology Reports 20, no. 1 (2008): 99-104. https://doi.org/10.3892/or.20.1.99
Copy and paste a formatted citation
x
Spandidos Publications style
Mkrtchyan H, Ghazaryan S, Avetisyan G, Hovhannisyan A, Muradyan L, Daghbashyan S, Karst C, Gross M, Hinreiner S, Aroutiounian R, Aroutiounian R, et al: Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome. Oncol Rep 20: 99-104, 2008.
APA
Mkrtchyan, H., Ghazaryan, S., Avetisyan, G., Hovhannisyan, A., Muradyan, L., Daghbashyan, S. ... Liehr, T. (2008). Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome. Oncology Reports, 20, 99-104. https://doi.org/10.3892/or.20.1.99
MLA
Mkrtchyan, H., Ghazaryan, S., Avetisyan, G., Hovhannisyan, A., Muradyan, L., Daghbashyan, S., Karst, C., Gross, M., Hinreiner, S., Aroutiounian, R., Liehr, T."Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome". Oncology Reports 20.1 (2008): 99-104.
Chicago
Mkrtchyan, H., Ghazaryan, S., Avetisyan, G., Hovhannisyan, A., Muradyan, L., Daghbashyan, S., Karst, C., Gross, M., Hinreiner, S., Aroutiounian, R., Liehr, T."Novel complex t(V;9;22) rearrangements in three cases with chronic myeloid leukemia and a rare translocation in a case with classical Philadelphia chromosome". Oncology Reports 20, no. 1 (2008): 99-104. https://doi.org/10.3892/or.20.1.99
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