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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2011 Volume 25 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation

  • Authors:
    • Bo K. Sun
    • Joo-Hang Kim
    • Hoan N. Nguyen
    • Seeun Oh
    • So Y. Kim
    • Soojin Choi
    • Hye J. Choi
    • Yong J. Lee
    • Jae J. Song

  • View Affiliations / Copyright

    Affiliations: Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea, Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, Republic of Korea
  • Pages: 537-544
    |
    Published online on: December 7, 2010
       https://doi.org/10.3892/or.2010.1079
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Abstract

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to activate mitogen-activated protein kinases (MAPKs) depending on caspase and mammalian sterile 20-like kinase 1 activations. However, the upstream molecule of MAPKs has not yet been identified. The mitogen-activated protein kinase kinase 1 (MEKK1) and the apoptosis signal-regulating kinase 1 (ASK1) are considered to be possible candidates for the action of MAPKKKs induced by TRAIL and the possibility of reactive oxygen species involvement has also been investigated. We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for TRAIL-induced c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation. The 14-3-3 θ was also shown to interact with and to dissociate from MEKK1 by TRAIL treatment, thus implicating the 14-3-3 protein as a negative regulator of MEKK1 activation. Taken together, we show herein that the upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner.

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Copy and paste a formatted citation
Spandidos Publications style
Sun BK, Kim J, Nguyen HN, Oh S, Kim SY, Choi S, Choi HJ, Lee YJ and Song JJ: MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. Oncol Rep 25: 537-544, 2011.
APA
Sun, B.K., Kim, J., Nguyen, H.N., Oh, S., Kim, S.Y., Choi, S. ... Song, J.J. (2011). MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. Oncology Reports, 25, 537-544. https://doi.org/10.3892/or.2010.1079
MLA
Sun, B. K., Kim, J., Nguyen, H. N., Oh, S., Kim, S. Y., Choi, S., Choi, H. J., Lee, Y. J., Song, J. J."MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation". Oncology Reports 25.2 (2011): 537-544.
Chicago
Sun, B. K., Kim, J., Nguyen, H. N., Oh, S., Kim, S. Y., Choi, S., Choi, H. J., Lee, Y. J., Song, J. J."MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation". Oncology Reports 25, no. 2 (2011): 537-544. https://doi.org/10.3892/or.2010.1079
Copy and paste a formatted citation
x
Spandidos Publications style
Sun BK, Kim J, Nguyen HN, Oh S, Kim SY, Choi S, Choi HJ, Lee YJ and Song JJ: MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. Oncol Rep 25: 537-544, 2011.
APA
Sun, B.K., Kim, J., Nguyen, H.N., Oh, S., Kim, S.Y., Choi, S. ... Song, J.J. (2011). MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. Oncology Reports, 25, 537-544. https://doi.org/10.3892/or.2010.1079
MLA
Sun, B. K., Kim, J., Nguyen, H. N., Oh, S., Kim, S. Y., Choi, S., Choi, H. J., Lee, Y. J., Song, J. J."MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation". Oncology Reports 25.2 (2011): 537-544.
Chicago
Sun, B. K., Kim, J., Nguyen, H. N., Oh, S., Kim, S. Y., Choi, S., Choi, H. J., Lee, Y. J., Song, J. J."MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation". Oncology Reports 25, no. 2 (2011): 537-544. https://doi.org/10.3892/or.2010.1079
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