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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2011 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas

  • Authors:
    • Xia Zhang
    • Xiaoyan Wang
    • Xingguo Song
    • Zengtao Wei
    • Chengjun Zhou
    • Faliang Zhu
    • Qun Wang
    • Chunhong Ma
    • Liling Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Department of Immunology, Shandong University School of Medicine, #44 Wenhua Xi Road, Jinan, Shandong 250012, P.R. China
  • Pages: 353-358
    |
    Published online on: December 13, 2010
       https://doi.org/10.3892/or.2010.1103
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Abstract

Programmed cell death 5 (PDCD5) is a novel apoptosis-promoting protein. Although the decreased expression of PDCD5 has been recently found in a few types of human tumors, the status and significance of PDCD5 in ovarian cancer has not been evaluated. In the present study, we detected PDCD5 expression in 20 normal human ovaries and 26 serous cystadenomas and 41 serous cystadenocarcinomas by RT-PCR, Western blotting and immunohistochemistry, and analyzed the relationship between PDCD5 expression and clinicopathological data or patient survival. PDCD5 was expressed in all normal ovaries and serous cystadenomas, 80% (16/20) of normal ovarian tissues and 76.9% (20/26) of serous cystadenomas with moderate or strong PDCD5 protein expression. In contrast, 22% (9/41) of serous cystadenocarcinomas had no detectable PDCD5 protein expression and 46.3% (19/41) exhibited weak PDCD5 expression. The overall expression of PDCD5 in serous cystadenocarcinoma was significantly lower compared with normal ovarian tissues or serous cystadenomas (p<0.01). Furthermore, lost or decreased PDCD5 expression in serous cystadenocarcinomas was associated significantly with FIGO stage (p<0.05) and poorer disease-specific survival of patients (p<0.05). In conclusion, our data suggest that lost or reduced PDCD5 expression may contribute to the pathogenesis of human serous cystadenocarcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Wang X, Song X, Wei Z, Zhou C, Zhu F, Wang Q, Ma C and Zhang L: Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncol Rep 25: 353-358, 2011.
APA
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F. ... Zhang, L. (2011). Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncology Reports, 25, 353-358. https://doi.org/10.3892/or.2010.1103
MLA
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F., Wang, Q., Ma, C., Zhang, L."Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas". Oncology Reports 25.2 (2011): 353-358.
Chicago
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F., Wang, Q., Ma, C., Zhang, L."Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas". Oncology Reports 25, no. 2 (2011): 353-358. https://doi.org/10.3892/or.2010.1103
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wang X, Song X, Wei Z, Zhou C, Zhu F, Wang Q, Ma C and Zhang L: Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncol Rep 25: 353-358, 2011.
APA
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F. ... Zhang, L. (2011). Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncology Reports, 25, 353-358. https://doi.org/10.3892/or.2010.1103
MLA
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F., Wang, Q., Ma, C., Zhang, L."Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas". Oncology Reports 25.2 (2011): 353-358.
Chicago
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F., Wang, Q., Ma, C., Zhang, L."Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas". Oncology Reports 25, no. 2 (2011): 353-358. https://doi.org/10.3892/or.2010.1103
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