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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2011 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Categorical meta-analysis of Osteopontin as a clinical cancer marker

  • Authors:
    • Georg F. Weber
    • G. Scott Lett
    • Ned C. Haubein
  • View Affiliations / Copyright

    Affiliations: James L. Winkle College of Pharmacy, University of Cincinnati Academic Health Center, 3225 Eden Avenue, Cincinnati, OH 45267-0004, USA
  • Pages: 433-441
    |
    Published online on: December 13, 2010
       https://doi.org/10.3892/or.2010.1106
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Abstract

Although extensive literature exists on cancer biomarkers few have found entry into clinical use. In particular, the cancer metastasis gene Osteopontin has been investigated extensively but it has not yet been applied to routine diagnostics. Here, we conduct a meta-analysis of data from the published literature and from RNA microarrays deposited in Oncomine. Osteopontin has been associated with 34 cancers. It is a marker for breast, cervical, colorectal, head and neck, liver, lung, ovarian and prostate cancers, as well as for sarcoma. Osteopontin is overexpressed in the metastases of colorectal cancers, lung cancers and melanomas, but not in ovarian cancer. Further, Osteopontin is indicative of the underlying mechanism of transformation only in certain virally induced tumors, where its function as a TH1 cytokine likely plays important roles. These results refine the value of Osteopontin as a cancer biomarker.

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Copy and paste a formatted citation
Spandidos Publications style
Weber GF, Lett GS and Haubein NC: Categorical meta-analysis of Osteopontin as a clinical cancer marker. Oncol Rep 25: 433-441, 2011.
APA
Weber, G.F., Lett, G.S., & Haubein, N.C. (2011). Categorical meta-analysis of Osteopontin as a clinical cancer marker. Oncology Reports, 25, 433-441. https://doi.org/10.3892/or.2010.1106
MLA
Weber, G. F., Lett, G. S., Haubein, N. C."Categorical meta-analysis of Osteopontin as a clinical cancer marker". Oncology Reports 25.2 (2011): 433-441.
Chicago
Weber, G. F., Lett, G. S., Haubein, N. C."Categorical meta-analysis of Osteopontin as a clinical cancer marker". Oncology Reports 25, no. 2 (2011): 433-441. https://doi.org/10.3892/or.2010.1106
Copy and paste a formatted citation
x
Spandidos Publications style
Weber GF, Lett GS and Haubein NC: Categorical meta-analysis of Osteopontin as a clinical cancer marker. Oncol Rep 25: 433-441, 2011.
APA
Weber, G.F., Lett, G.S., & Haubein, N.C. (2011). Categorical meta-analysis of Osteopontin as a clinical cancer marker. Oncology Reports, 25, 433-441. https://doi.org/10.3892/or.2010.1106
MLA
Weber, G. F., Lett, G. S., Haubein, N. C."Categorical meta-analysis of Osteopontin as a clinical cancer marker". Oncology Reports 25.2 (2011): 433-441.
Chicago
Weber, G. F., Lett, G. S., Haubein, N. C."Categorical meta-analysis of Osteopontin as a clinical cancer marker". Oncology Reports 25, no. 2 (2011): 433-441. https://doi.org/10.3892/or.2010.1106
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