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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2011 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis

  • Authors:
    • Haruhiko Aoyagi
    • Satoru Iida
    • Hiroyuki Uetake
    • Toshiaki Ishikawa
    • Yoko Takagi
    • Hirotoshi Kobayashi
    • Tetsuro Higuchi
    • Masamichi Yasuno
    • Masayuki Enomoto
    • Kenichi Sugihara

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
  • Pages: 789-794
    |
    Published online on: December 21, 2010
       https://doi.org/10.3892/or.2010.1118
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Abstract

Colorectal cancer (CRC) is caused by an accumulation of genetic alterations and epigenetic alterations. The molecular classification of CRCs based on genetic alterations and epigenetic alterations is evolving. Here, we examined mutations and methylation status in CRCs to determine if the combination of genetic and epigenetic alterations predicts prognosis. We examined 134 sporadic CRCs. We used the direct sequencing method to identify mutations in BRAF and AKT1, which are downstream of KRAS and PIK3CA, respectively, in the EGFR pathway. We used the Methylight method to determine the methylation status of hMLH1, p16, MINT1, MINT2 and MINT31. Both BRAF and AKT1 mutations were found in only one case (0.75%). Aberrant methylation of hMLH1, p16, MINT1, MINT2 and MINT31 was detected in 22.4, 35.1, 32.8, 59.7 and 41.0% of cases, respectively. The clinicopathological factors were not significantly correlated to mutation or methylation. Among the patients who had no mutation in the EGFR pathway, the overall survival was significantly shorter in the patients with methylation compared to the patients with no methylation in hMLH1 and p16 (p=0.0318). Methylation could play a key role in the prognosis of patients without mutations in the EGFR pathway. The combination of genetic and epigenetic alterations may be a good marker for the prognosis of CRC patients.

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Copy and paste a formatted citation
Spandidos Publications style
Aoyagi H, Iida S, Uetake H, Ishikawa T, Takagi Y, Kobayashi H, Higuchi T, Yasuno M, Enomoto M, Sugihara K, Sugihara K, et al: Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis. Oncol Rep 25: 789-794, 2011.
APA
Aoyagi, H., Iida, S., Uetake, H., Ishikawa, T., Takagi, Y., Kobayashi, H. ... Sugihara, K. (2011). Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis. Oncology Reports, 25, 789-794. https://doi.org/10.3892/or.2010.1118
MLA
Aoyagi, H., Iida, S., Uetake, H., Ishikawa, T., Takagi, Y., Kobayashi, H., Higuchi, T., Yasuno, M., Enomoto, M., Sugihara, K."Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis". Oncology Reports 25.3 (2011): 789-794.
Chicago
Aoyagi, H., Iida, S., Uetake, H., Ishikawa, T., Takagi, Y., Kobayashi, H., Higuchi, T., Yasuno, M., Enomoto, M., Sugihara, K."Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis". Oncology Reports 25, no. 3 (2011): 789-794. https://doi.org/10.3892/or.2010.1118
Copy and paste a formatted citation
x
Spandidos Publications style
Aoyagi H, Iida S, Uetake H, Ishikawa T, Takagi Y, Kobayashi H, Higuchi T, Yasuno M, Enomoto M, Sugihara K, Sugihara K, et al: Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis. Oncol Rep 25: 789-794, 2011.
APA
Aoyagi, H., Iida, S., Uetake, H., Ishikawa, T., Takagi, Y., Kobayashi, H. ... Sugihara, K. (2011). Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis. Oncology Reports, 25, 789-794. https://doi.org/10.3892/or.2010.1118
MLA
Aoyagi, H., Iida, S., Uetake, H., Ishikawa, T., Takagi, Y., Kobayashi, H., Higuchi, T., Yasuno, M., Enomoto, M., Sugihara, K."Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis". Oncology Reports 25.3 (2011): 789-794.
Chicago
Aoyagi, H., Iida, S., Uetake, H., Ishikawa, T., Takagi, Y., Kobayashi, H., Higuchi, T., Yasuno, M., Enomoto, M., Sugihara, K."Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis". Oncology Reports 25, no. 3 (2011): 789-794. https://doi.org/10.3892/or.2010.1118
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