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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2011 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2011 Volume 25 Issue 3

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Article

Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma

  • Authors:
    • Shunichiro Iwasawa
    • Yukio Yamano
    • Yuichi Takiguchi
    • Hideki Tanzawa
    • Koichiro Tatsumi
    • Katsuhiro Uzawa

  • View Affiliations / Copyright

    Affiliations: Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan, Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
  • Pages: 637-644
    |
    Published online on: December 30, 2010
       https://doi.org/10.3892/or.2010.1131
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Abstract

Thioredoxin reductase 1 (TrxR1) catalyzes the nicotinamide adenine dinucleotide phosphate-dependent reduction of oxidized thioredoxin (Trx). Trx, which is over-expressed in many human tumors, is a selenocysteine-containing protein associated with cell proliferation and apoptosis inhibition. This selenium-containing redox system regulates the activity of various enzymes and counteracts oxidative stress in cells such as hypoxia and cytotoxic agents. Consequently, TrxR1 could play an important role in tumor progression and resistance to chemotherapy due to its anti-apoptotic functions. To characterize cancer-related gene expression changes in oral squamous cell carcinomas (OSCC), we compared the gene expression profiles in OSCC primary tumors with patient-matched normal oral epithelium. Microarray analysis showed TrxR1 upregulation in primary tumors. Gene ontology analysis showed highly significant cancer-related function. The TrxR1 expression examined by immunohistochemistry was correlated with regional lymph node metastasis (P<0.05) and the clinical stages of 50 patients (P<0.01). Overexpression of TrxR1 could contribute to cancer progression and might be a potential molecular marker for therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Iwasawa S, Yamano Y, Takiguchi Y, Tanzawa H, Tatsumi K and Uzawa K: Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma. Oncol Rep 25: 637-644, 2011.
APA
Iwasawa, S., Yamano, Y., Takiguchi, Y., Tanzawa, H., Tatsumi, K., & Uzawa, K. (2011). Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma. Oncology Reports, 25, 637-644. https://doi.org/10.3892/or.2010.1131
MLA
Iwasawa, S., Yamano, Y., Takiguchi, Y., Tanzawa, H., Tatsumi, K., Uzawa, K."Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma". Oncology Reports 25.3 (2011): 637-644.
Chicago
Iwasawa, S., Yamano, Y., Takiguchi, Y., Tanzawa, H., Tatsumi, K., Uzawa, K."Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma". Oncology Reports 25, no. 3 (2011): 637-644. https://doi.org/10.3892/or.2010.1131
Copy and paste a formatted citation
x
Spandidos Publications style
Iwasawa S, Yamano Y, Takiguchi Y, Tanzawa H, Tatsumi K and Uzawa K: Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma. Oncol Rep 25: 637-644, 2011.
APA
Iwasawa, S., Yamano, Y., Takiguchi, Y., Tanzawa, H., Tatsumi, K., & Uzawa, K. (2011). Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma. Oncology Reports, 25, 637-644. https://doi.org/10.3892/or.2010.1131
MLA
Iwasawa, S., Yamano, Y., Takiguchi, Y., Tanzawa, H., Tatsumi, K., Uzawa, K."Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma". Oncology Reports 25.3 (2011): 637-644.
Chicago
Iwasawa, S., Yamano, Y., Takiguchi, Y., Tanzawa, H., Tatsumi, K., Uzawa, K."Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma". Oncology Reports 25, no. 3 (2011): 637-644. https://doi.org/10.3892/or.2010.1131
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