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Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound

  • Authors:
    • Hirotaka Hoshi
    • Hikaru Saito
    • Hiroko Iijima
    • Motoyuki Uchida
    • Tsutomu Wada
    • Gentaro Ito
    • Hiroaki Tanaka
    • Tetsuji Sawada
    • Kosei Hirakawa

  • View Affiliations

  • Published online on: January 19, 2011     https://doi.org/10.3892/or.2011.1155
  • Pages: 905-913
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Abstract

Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. The results obtained suggest that PSK reaches the tumor tissue in its active form and exhibits antitumor effects against MethA cells.

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April 2011
Volume 25 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T and Hirakawa K: Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound. Oncol Rep 25: 905-913, 2011
APA
Hoshi, H., Saito, H., Iijima, H., Uchida, M., Wada, T., Ito, G. ... Hirakawa, K. (2011). Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound. Oncology Reports, 25, 905-913. https://doi.org/10.3892/or.2011.1155
MLA
Hoshi, H., Saito, H., Iijima, H., Uchida, M., Wada, T., Ito, G., Tanaka, H., Sawada, T., Hirakawa, K."Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound". Oncology Reports 25.4 (2011): 905-913.
Chicago
Hoshi, H., Saito, H., Iijima, H., Uchida, M., Wada, T., Ito, G., Tanaka, H., Sawada, T., Hirakawa, K."Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound". Oncology Reports 25, no. 4 (2011): 905-913. https://doi.org/10.3892/or.2011.1155