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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2011 Volume 25 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells

  • Authors:
    • Qing Luo
    • Mei Zhao
    • Jialing Zhong
    • Yiming Ma
    • Guohua Deng
    • Jian Liu
    • Jia Wang
    • Xinghua Yuan
    • Changzhi Huang

  • View Affiliations / Copyright

    Affiliations: Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China, Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Beijing 100021, P.R. China
  • Pages: 1117-1123
    |
    Published online on: January 31, 2011
       https://doi.org/10.3892/or.2011.1171
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Abstract

Many key proteins are down-regulated or lose their function during cancer genesis and accelerate the progress of cancer. We found that nuclear apoptosis-inducing factor 1 (NAIF1) was highly expressed in normal gastric tissues but was down-regulated or lost in gastric cancer tissues (P<0.001). NAIF1 expression was higher in well-differentiated (P=0.004) than in moderately- or poorly-differentiated gastric cancer. NAIF1 expression was associated with different T stages (P=0.024). In vitro, NAIF1 can inhibit tumor cell proliferation and induce G0/G1 phase cell cycle arrest in the MKN45 cell line. NAIF1 can induce apoptosis through activation of procaspase-9 rather than procaspase-8 followed by activation of the caspase-3 pathway. We designed and constructed two truncation mutants, pEGFP-N1-NLS and pEGFP-N1-GRR, and identified the N-terminal 1-90 amino acid domain of NAIF1, which is a helix-turn-helix motif and which was sufficient for inducing apoptosis. Therefore, these findings suggest that NAIF1 plays an inhibitory role in the initial steps of gastric cancer genesis and may provide new strategies for developing anti-cancer drugs using small molecular polypeptides.

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Copy and paste a formatted citation
Spandidos Publications style
Luo Q, Zhao M, Zhong J, Ma Y, Deng G, Liu J, Wang J, Yuan X and Huang C: NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells. Oncol Rep 25: 1117-1123, 2011.
APA
Luo, Q., Zhao, M., Zhong, J., Ma, Y., Deng, G., Liu, J. ... Huang, C. (2011). NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells. Oncology Reports, 25, 1117-1123. https://doi.org/10.3892/or.2011.1171
MLA
Luo, Q., Zhao, M., Zhong, J., Ma, Y., Deng, G., Liu, J., Wang, J., Yuan, X., Huang, C."NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells". Oncology Reports 25.4 (2011): 1117-1123.
Chicago
Luo, Q., Zhao, M., Zhong, J., Ma, Y., Deng, G., Liu, J., Wang, J., Yuan, X., Huang, C."NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells". Oncology Reports 25, no. 4 (2011): 1117-1123. https://doi.org/10.3892/or.2011.1171
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Q, Zhao M, Zhong J, Ma Y, Deng G, Liu J, Wang J, Yuan X and Huang C: NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells. Oncol Rep 25: 1117-1123, 2011.
APA
Luo, Q., Zhao, M., Zhong, J., Ma, Y., Deng, G., Liu, J. ... Huang, C. (2011). NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells. Oncology Reports, 25, 1117-1123. https://doi.org/10.3892/or.2011.1171
MLA
Luo, Q., Zhao, M., Zhong, J., Ma, Y., Deng, G., Liu, J., Wang, J., Yuan, X., Huang, C."NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells". Oncology Reports 25.4 (2011): 1117-1123.
Chicago
Luo, Q., Zhao, M., Zhong, J., Ma, Y., Deng, G., Liu, J., Wang, J., Yuan, X., Huang, C."NAIF1 is down-regulated in gastric cancer and promotes apoptosis through the caspase-9 pathway in human MKN45 cells". Oncology Reports 25, no. 4 (2011): 1117-1123. https://doi.org/10.3892/or.2011.1171
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