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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2011 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells

  • Authors:
    • Xueli Wang
    • Bo Chen
    • Wei Xu
    • Shifeng Liu
    • Weihong Zhao
    • Jianqing Wu

  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China, Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, P.R. China
  • Pages: 1465-1472
    |
    Published online on: February 9, 2011
       https://doi.org/10.3892/or.2011.1178
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Abstract

Although the roles of soluble CD40 ligand (sCD40L) or the klotho gene in lung cancer cells have been studied, little is known about the functions of klotho combined with sCD40L in lung cancer. The present study was designed to investigate the biological effects of klotho combined with sCD40L on the A549 lung cancer cell line (CD40 positive) and their possible mechanisms. Lung cancer A549 cells were chosen as target cells and CD40 signals were stimulated by soluble CD40 ligand (sCD40L). In this study, we found that klotho, soluble CD40 ligand and their combination can increase cell proliferation inhibition and the apoptosis rate in A549 cells by inhibiting the cell cycle, up-regulating Bax gene expression and (or) down-regulating Bcl-2 gene expression; and their combination has a stronger effect on A549 cell apoptosis and proliferation inhibition compared to klotho or sCD40L alone. These data suggest that the combination of klotho and sCD40L may provide an efficient method to treat non-small cell lung cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Chen B, Xu W, Liu S, Zhao W and Wu J: Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncol Rep 25: 1465-1472, 2011.
APA
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., & Wu, J. (2011). Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncology Reports, 25, 1465-1472. https://doi.org/10.3892/or.2011.1178
MLA
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., Wu, J."Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells". Oncology Reports 25.5 (2011): 1465-1472.
Chicago
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., Wu, J."Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells". Oncology Reports 25, no. 5 (2011): 1465-1472. https://doi.org/10.3892/or.2011.1178
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Chen B, Xu W, Liu S, Zhao W and Wu J: Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncol Rep 25: 1465-1472, 2011.
APA
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., & Wu, J. (2011). Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncology Reports, 25, 1465-1472. https://doi.org/10.3892/or.2011.1178
MLA
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., Wu, J."Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells". Oncology Reports 25.5 (2011): 1465-1472.
Chicago
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., Wu, J."Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells". Oncology Reports 25, no. 5 (2011): 1465-1472. https://doi.org/10.3892/or.2011.1178
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