Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells

  • Authors:
    • Xueli Wang
    • Bo Chen
    • Wei Xu
    • Shifeng Liu
    • Weihong Zhao
    • Jianqing Wu
  • View Affiliations

  • Published online on: February 9, 2011     https://doi.org/10.3892/or.2011.1178
  • Pages: 1465-1472
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Abstract

Although the roles of soluble CD40 ligand (sCD40L) or the klotho gene in lung cancer cells have been studied, little is known about the functions of klotho combined with sCD40L in lung cancer. The present study was designed to investigate the biological effects of klotho combined with sCD40L on the A549 lung cancer cell line (CD40 positive) and their possible mechanisms. Lung cancer A549 cells were chosen as target cells and CD40 signals were stimulated by soluble CD40 ligand (sCD40L). In this study, we found that klotho, soluble CD40 ligand and their combination can increase cell proliferation inhibition and the apoptosis rate in A549 cells by inhibiting the cell cycle, up-regulating Bax gene expression and (or) down-regulating Bcl-2 gene expression; and their combination has a stronger effect on A549 cell apoptosis and proliferation inhibition compared to klotho or sCD40L alone. These data suggest that the combination of klotho and sCD40L may provide an efficient method to treat non-small cell lung cancer.

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May 2011
Volume 25 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Chen B, Xu W, Liu S, Zhao W and Wu J: Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncol Rep 25: 1465-1472, 2011
APA
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., & Wu, J. (2011). Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncology Reports, 25, 1465-1472. https://doi.org/10.3892/or.2011.1178
MLA
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., Wu, J."Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells". Oncology Reports 25.5 (2011): 1465-1472.
Chicago
Wang, X., Chen, B., Xu, W., Liu, S., Zhao, W., Wu, J."Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells". Oncology Reports 25, no. 5 (2011): 1465-1472. https://doi.org/10.3892/or.2011.1178