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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2011 Volume 25 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma

  • Authors:
    • Satu Koivula
    • Erkka Valo
    • Anna Raunio
    • Sampsa Hautaniemi
    • Sirpa Leppä

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland, Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, FIN-00029 Helsinki, Finland
  • Pages: 1183-1190
    |
    Published online on: February 10, 2011
       https://doi.org/10.3892/or.2011.1179
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Abstract

Rituximab, a CD20-specific antibody, is used with chemotherapy as a treatment for diffuse large B cell lymphoma (DLBCL). Although many patients benefit from the addition of rituximab to chemotherapy, a favourable response is not achieved in approximately 30% of cases. This sets a prerequisite to better understand the response and resistance mechanisms of rituximab. To do so, we analyzed the gene expression profiles of one rituximab unresponsive and two responsive DLBCL cell lines. In the responsive cells, rituximab affected the expression of genes related to apoptosis, lymphocyte signaling and cytokine response. Our data show rituximab-response to be associated with gene expression in classical signaling cascades involved in cell growth and differentiation, such as previously identified MAPK and completely novel Wnt and TGF-β pathways. Furthermore, our findings support earlier observations that rituximab can induce direct apoptosis and suggest the cell of origin to be associated with the cellular outcome. After validation of cellular results, we used a cohort of 233 R-CHOP treated DLBCL patients and found several of the most differentiating genes to have impact on survival. Together, the results provide an advanced picture of the CD20 mediated signaling of DLBCL cells and may provide new targets in future treatment protocols.

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Copy and paste a formatted citation
Spandidos Publications style
Koivula S, Valo E, Raunio A, Hautaniemi S and Leppä S: Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma. Oncol Rep 25: 1183-1190, 2011.
APA
Koivula, S., Valo, E., Raunio, A., Hautaniemi, S., & Leppä, S. (2011). Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma. Oncology Reports, 25, 1183-1190. https://doi.org/10.3892/or.2011.1179
MLA
Koivula, S., Valo, E., Raunio, A., Hautaniemi, S., Leppä, S."Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma". Oncology Reports 25.4 (2011): 1183-1190.
Chicago
Koivula, S., Valo, E., Raunio, A., Hautaniemi, S., Leppä, S."Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma". Oncology Reports 25, no. 4 (2011): 1183-1190. https://doi.org/10.3892/or.2011.1179
Copy and paste a formatted citation
x
Spandidos Publications style
Koivula S, Valo E, Raunio A, Hautaniemi S and Leppä S: Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma. Oncol Rep 25: 1183-1190, 2011.
APA
Koivula, S., Valo, E., Raunio, A., Hautaniemi, S., & Leppä, S. (2011). Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma. Oncology Reports, 25, 1183-1190. https://doi.org/10.3892/or.2011.1179
MLA
Koivula, S., Valo, E., Raunio, A., Hautaniemi, S., Leppä, S."Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma". Oncology Reports 25.4 (2011): 1183-1190.
Chicago
Koivula, S., Valo, E., Raunio, A., Hautaniemi, S., Leppä, S."Rituximab regulates signaling pathways and alters gene expression associated with cell death and survival in diffuse large B-cell lymphoma". Oncology Reports 25, no. 4 (2011): 1183-1190. https://doi.org/10.3892/or.2011.1179
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