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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2011 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells

  • Authors:
    • Xiaoxue Xie
    • Xunfan Shao
    • Fuping Gao
    • Hekun Jin
    • Jumei Zhou
    • Lehui Du
    • Yingying Zhang
    • Weiwei Ouyang
    • Xiaowen Wang
    • Lingyun Zhao
    • Xiaodong Zhang
    • Jintian Tang

  • View Affiliations / Copyright

    Affiliations: Affiliated Tumor Hospital of Guangzhou Medical College, Guangdong 510095, P.R. China, Institute of Medical Physics and Engineering, Department of Engineering Physics, Tsinghua University, Beijing 100084, P.R. China
  • Pages: 1573-1579
    |
    Published online on: March 29, 2011
       https://doi.org/10.3892/or.2011.1240
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Abstract

The present study aimed to investigate heating-induced alterations of breast cancer cell invasion abilities and the potential mechanisms associated with TGF-β1 expression. MCF-7 cells were heated at 43, 45, 47 and 37˚C for 30 min. In vitro cell invasion ability was evaluated by matrigel invasion assay. The activity of matrix metalloproteinase (MMP)-2/9 was investigated by gelatin zymographic assays. Expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) was investigated by immunocytochemistry and RT-PCR. Apoptosis was analysed by flow-cytometry. The invasive potential of MCF-7 cells was reduced by heating, and MMP-2/9 secretion and enzymatic activity were suppressed. Furthermore, VEGF and TGF-β1 mRNA and proteins were suppressed by hyperthermia. These results suggest that down-regulation of the expression of TGF-β1, EGF and MMPs by hyperthermia probably accounts for the inhibition of the invasive abilities of MCF-7 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Xie X, Shao X, Gao F, Jin H, Zhou J, Du L, Zhang Y, Ouyang W, Wang X, Zhao L, Zhao L, et al: Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells. Oncol Rep 25: 1573-1579, 2011.
APA
Xie, X., Shao, X., Gao, F., Jin, H., Zhou, J., Du, L. ... Tang, J. (2011). Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells. Oncology Reports, 25, 1573-1579. https://doi.org/10.3892/or.2011.1240
MLA
Xie, X., Shao, X., Gao, F., Jin, H., Zhou, J., Du, L., Zhang, Y., Ouyang, W., Wang, X., Zhao, L., Zhang, X., Tang, J."Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells". Oncology Reports 25.6 (2011): 1573-1579.
Chicago
Xie, X., Shao, X., Gao, F., Jin, H., Zhou, J., Du, L., Zhang, Y., Ouyang, W., Wang, X., Zhao, L., Zhang, X., Tang, J."Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells". Oncology Reports 25, no. 6 (2011): 1573-1579. https://doi.org/10.3892/or.2011.1240
Copy and paste a formatted citation
x
Spandidos Publications style
Xie X, Shao X, Gao F, Jin H, Zhou J, Du L, Zhang Y, Ouyang W, Wang X, Zhao L, Zhao L, et al: Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells. Oncol Rep 25: 1573-1579, 2011.
APA
Xie, X., Shao, X., Gao, F., Jin, H., Zhou, J., Du, L. ... Tang, J. (2011). Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells. Oncology Reports, 25, 1573-1579. https://doi.org/10.3892/or.2011.1240
MLA
Xie, X., Shao, X., Gao, F., Jin, H., Zhou, J., Du, L., Zhang, Y., Ouyang, W., Wang, X., Zhao, L., Zhang, X., Tang, J."Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells". Oncology Reports 25.6 (2011): 1573-1579.
Chicago
Xie, X., Shao, X., Gao, F., Jin, H., Zhou, J., Du, L., Zhang, Y., Ouyang, W., Wang, X., Zhao, L., Zhang, X., Tang, J."Effect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells". Oncology Reports 25, no. 6 (2011): 1573-1579. https://doi.org/10.3892/or.2011.1240
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