microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4

  • Authors:
    • Rong Yin
    • Shuai Zhang
    • Yaqin Wu
    • Xiaohu Fan
    • Feng Jiang
    • Zhi Zhang
    • Dongjie Feng
    • Xirong Guo
    • Lin Xu
  • View Affiliations

  • Published online on: April 7, 2011     https://doi.org/10.3892/or.2011.1252
  • Pages:1747-1754
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Recent studies demonstrated that microRNA-145 is downregulated in human cancer cells and may function as a tumor suppressor. However, its role in lung cancer tumorigenesis remains unclear. Here, we demonstrated that upregulation of miR-145 reduced the proliferation and invasion as well as the ratio of CD133-positive initiating cells and the tumorosphere growth capacity of the human lung adenocarcinoma A549 cell line. The direct targeting of miR-145 to OCT4 mRNA was predicted by bioinformatic analysis and validated by a luciferase reporter system. We, therefore, confirmed that miR-145 can impair the proliferation of human lung adenocarcinoma-initiating cells by targeting OCT4 and leads to inhibition of lung cancer development.

Related Articles

Journal Cover

June 2011
Volume 25 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yin, R., Zhang, S., Wu, Y., Fan, X., Jiang, F., Zhang, Z. ... Xu, L. (2011). microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4. Oncology Reports, 25, 1747-1754. https://doi.org/10.3892/or.2011.1252
MLA
Yin, R., Zhang, S., Wu, Y., Fan, X., Jiang, F., Zhang, Z., Feng, D., Guo, X., Xu, L."microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4". Oncology Reports 25.6 (2011): 1747-1754.
Chicago
Yin, R., Zhang, S., Wu, Y., Fan, X., Jiang, F., Zhang, Z., Feng, D., Guo, X., Xu, L."microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4". Oncology Reports 25, no. 6 (2011): 1747-1754. https://doi.org/10.3892/or.2011.1252