Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas

  • Authors:
    • Anna Kwasniewska
    • Krzysztof Postawski
    • Anna Gozdzicka-Jozefiak
    • Wojciech Kwasniewski
    • Ewelina Grywalska
    • Malgorzata Zdunek
    • Elzbieta Korobowicz
  • View Affiliations

  • Published online on: April 12, 2011     https://doi.org/10.3892/or.2011.1256
  • Pages: 153-160
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Abstract

Human papillomavirus (HPV) is widely accepted as the main cause of cervical cancer. However, the presence of HPV DNA does not inescapably lead to the development of the cancerous phenotype of the infected cell. Therefore, it is considered that the induction of full cancerous expression of HPV requires additional cofactors. The aim of this study was to assess the expression of estrogen receptor α (ERα) and progesterone receptor (PR) in archived tissue blocks of squamous cell carcinoma and adenocarcinoma of the uterine cervix and to ascertain whether expression of these receptors is associated with the presence of HPV DNA. The investigation was performed using formalin-fixed, paraffin-embedded cervical cancer specimens obtained from 250 women who underwent surgery for histologically confirmed neoplastic lesions. The control group consisted of normal cervical tissues obtained from 50 patients who underwent myomectomy. The results of this study revealed that the expression of ER and PR in planoepithelial cancers and adenocarcinomas of the cervix were decreased to undetectable levels. Only in singular cases in the pattern of staining the expression of ER and PR was noted. In stromal cells of the tested neoplasms, higher expression of both types of receptors was found. Comparison of the expression of ER and PR in the staining pattern and stroma of both squamous cell carcinoma and adenocarcioma of the cervix, showed statistically higher expression in the stromal cells. Strong expression (+1, +2, +3) of ER and PR was noted in the stromal cells irrespective of HPV infection, histopathological type of cancer, and clinical and histopathological grade.

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July 2011
Volume 26 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kwasniewska A, Postawski K, Gozdzicka-Jozefiak A, Kwasniewski W, Grywalska E, Zdunek M and Korobowicz E: Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas. Oncol Rep 26: 153-160, 2011
APA
Kwasniewska, A., Postawski, K., Gozdzicka-Jozefiak, A., Kwasniewski, W., Grywalska, E., Zdunek, M., & Korobowicz, E. (2011). Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas. Oncology Reports, 26, 153-160. https://doi.org/10.3892/or.2011.1256
MLA
Kwasniewska, A., Postawski, K., Gozdzicka-Jozefiak, A., Kwasniewski, W., Grywalska, E., Zdunek, M., Korobowicz, E."Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas". Oncology Reports 26.1 (2011): 153-160.
Chicago
Kwasniewska, A., Postawski, K., Gozdzicka-Jozefiak, A., Kwasniewski, W., Grywalska, E., Zdunek, M., Korobowicz, E."Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas". Oncology Reports 26, no. 1 (2011): 153-160. https://doi.org/10.3892/or.2011.1256