Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance

  • Authors:
    • Yasuhiro Tada
    • Akira Yokomizo
    • Masaki Shiota
    • Yoohyun Song
    • Eiji Kashiwagi
    • Kentaro Kuroiwa
    • Yoshinao Oda
    • Seiji Naito
  • View Affiliations

  • Published online on: April 20, 2011     https://doi.org/10.3892/or.2011.1274
  • Pages: 161-167
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Abstract

The development of resistance to cisplatin during treatment of testicular cancer constitutes a major obstacle to the cure of testicular cancer. To resolve its mechanism will provide useful information for making clinical decisions. We found 4 and 15 gene expressions were, respectively, up-regulated and down-regulated in cisplatin-resistant testicular cancer NEC-8/DDP cells compared with their parental NEC-8 cells (about 2.5-fold) using cDNA microarray analysis. After screening, we selected the ENTPD6 among these 19 genes. ENTPD6 was less expressed in cancerous region compared with that in non-cancerous lesion. In addition, ENTPD6 expression in seminoma was higher than that in other testicular tumors. ENTPD6 expression was involved in cellular sensitivity to cisplatin through an interaction with E-cadherin. ENTPD6 is a promising molecular biomarker of cisplatin resistance in testicular cancer, and also a novel therapeutical target modulating cisplatin resistance in testicular cancer.

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July 2011
Volume 26 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tada Y, Yokomizo A, Shiota M, Song Y, Kashiwagi E, Kuroiwa K, Oda Y and Naito S: Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance. Oncol Rep 26: 161-167, 2011.
APA
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K. ... Naito, S. (2011). Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance. Oncology Reports, 26, 161-167. https://doi.org/10.3892/or.2011.1274
MLA
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K., Oda, Y., Naito, S."Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance". Oncology Reports 26.1 (2011): 161-167.
Chicago
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K., Oda, Y., Naito, S."Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance". Oncology Reports 26, no. 1 (2011): 161-167. https://doi.org/10.3892/or.2011.1274