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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2011 Volume 26 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance

  • Authors:
    • Yasuhiro Tada
    • Akira Yokomizo
    • Masaki Shiota
    • Yoohyun Song
    • Eiji Kashiwagi
    • Kentaro Kuroiwa
    • Yoshinao Oda
    • Seiji Naito

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • Pages: 161-167
    |
    Published online on: April 20, 2011
       https://doi.org/10.3892/or.2011.1274
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Abstract

The development of resistance to cisplatin during treatment of testicular cancer constitutes a major obstacle to the cure of testicular cancer. To resolve its mechanism will provide useful information for making clinical decisions. We found 4 and 15 gene expressions were, respectively, up-regulated and down-regulated in cisplatin-resistant testicular cancer NEC-8/DDP cells compared with their parental NEC-8 cells (about 2.5-fold) using cDNA microarray analysis. After screening, we selected the ENTPD6 among these 19 genes. ENTPD6 was less expressed in cancerous region compared with that in non-cancerous lesion. In addition, ENTPD6 expression in seminoma was higher than that in other testicular tumors. ENTPD6 expression was involved in cellular sensitivity to cisplatin through an interaction with E-cadherin. ENTPD6 is a promising molecular biomarker of cisplatin resistance in testicular cancer, and also a novel therapeutical target modulating cisplatin resistance in testicular cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tada Y, Yokomizo A, Shiota M, Song Y, Kashiwagi E, Kuroiwa K, Oda Y and Naito S: Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance. Oncol Rep 26: 161-167, 2011.
APA
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K. ... Naito, S. (2011). Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance. Oncology Reports, 26, 161-167. https://doi.org/10.3892/or.2011.1274
MLA
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K., Oda, Y., Naito, S."Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance". Oncology Reports 26.1 (2011): 161-167.
Chicago
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K., Oda, Y., Naito, S."Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance". Oncology Reports 26, no. 1 (2011): 161-167. https://doi.org/10.3892/or.2011.1274
Copy and paste a formatted citation
x
Spandidos Publications style
Tada Y, Yokomizo A, Shiota M, Song Y, Kashiwagi E, Kuroiwa K, Oda Y and Naito S: Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance. Oncol Rep 26: 161-167, 2011.
APA
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K. ... Naito, S. (2011). Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance. Oncology Reports, 26, 161-167. https://doi.org/10.3892/or.2011.1274
MLA
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K., Oda, Y., Naito, S."Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance". Oncology Reports 26.1 (2011): 161-167.
Chicago
Tada, Y., Yokomizo, A., Shiota, M., Song, Y., Kashiwagi, E., Kuroiwa, K., Oda, Y., Naito, S."Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance". Oncology Reports 26, no. 1 (2011): 161-167. https://doi.org/10.3892/or.2011.1274
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