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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2011 Volume 26 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis

  • Authors:
    • Weiwei Liu
    • Wenling Zheng
    • Jun Xie
    • Bao Zhang
    • Wenli Ma
    • Xianjiu Chen

  • View Affiliations / Copyright

    Affiliations: The Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, P.R. China, Biochemistry and Molecular Department, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan 030001, P.R. China
  • Pages: 265-274
    |
    Published online on: April 26, 2011
       https://doi.org/10.3892/or.2011.1281
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Abstract

The aim of this study was to identify genes that are predictive of carcinogenic change in patients of oral leukoplakia (OLK) using a cancer-related microarray. Candidate biomarkers were discovered using the Oligo GEArray OHS-802 and validated on independent samples by semi-quantitative reverse transcription-PCR (RT-PCR) and real-time RT-PCR. Both the discovery and the validation cohorts of samples included normal oral tissues, OLK tissues and oral squamous cell carcinoma (OSCC) tissues. Based on the microarray results, we found that there were nine genes successively up-regulated or down-regulated more than 2-fold between the normal group and OLK group and then again between the OLK group and OSCC group. The expression levels of the nine signature genes had statistically significant differences (p<0.05) between the OLK and normal groups and between the OSCC and OLK groups. In summary, the expression of the 9 signature genes might be representative of OLK carcinogenesis. A cancer-related microarray was used to identify a panel of candidate biomarkers for determining carcinogenesis of OLK lesions, in combination with semi-quantitative and real-time RT-PCR to validate the results. Our data indicated that alterations in gene expression that result in carcinogenesis can be identified in precancerous oral tissues.

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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Zheng W, Xie J, Zhang B, Ma W and Chen X: Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis. Oncol Rep 26: 265-274, 2011.
APA
Liu, W., Zheng, W., Xie, J., Zhang, B., Ma, W., & Chen, X. (2011). Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis. Oncology Reports, 26, 265-274. https://doi.org/10.3892/or.2011.1281
MLA
Liu, W., Zheng, W., Xie, J., Zhang, B., Ma, W., Chen, X."Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis". Oncology Reports 26.1 (2011): 265-274.
Chicago
Liu, W., Zheng, W., Xie, J., Zhang, B., Ma, W., Chen, X."Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis". Oncology Reports 26, no. 1 (2011): 265-274. https://doi.org/10.3892/or.2011.1281
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Zheng W, Xie J, Zhang B, Ma W and Chen X: Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis. Oncol Rep 26: 265-274, 2011.
APA
Liu, W., Zheng, W., Xie, J., Zhang, B., Ma, W., & Chen, X. (2011). Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis. Oncology Reports, 26, 265-274. https://doi.org/10.3892/or.2011.1281
MLA
Liu, W., Zheng, W., Xie, J., Zhang, B., Ma, W., Chen, X."Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis". Oncology Reports 26.1 (2011): 265-274.
Chicago
Liu, W., Zheng, W., Xie, J., Zhang, B., Ma, W., Chen, X."Identification of genes related to carcinogenesis of oral leukoplakia by oligo cancer microarray analysis". Oncology Reports 26, no. 1 (2011): 265-274. https://doi.org/10.3892/or.2011.1281
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