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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2011 Volume 26 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma

  • Authors:
    • Ming-Hua Ge
    • Chao Chen
    • Jia-Jie Xu
    • Zhi-Qiang Ling

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Zhejiang Province Cancer Hospital, Hangzhou 310022, P.R. China, Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, P.R. China
  • Pages: 349-357
    |
    Published online on: April 28, 2011
       https://doi.org/10.3892/or.2011.1282
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Abstract

To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference (P<0.001). There was a significant correlation between RUNX3 methylation and various clinicopathological parameters of ACCs, such as perineural invasion, lymph node involvement, T-stage and distant metastasis (P<0.001). RUNX3 methylation was a significant predictor of the 5-year disease-free survival in ACC patients after surgery. Partial methylation was found in all 3 ACC cell lines, and the reactivation and more potent expression of RUNX3 was induced by 5-triazole-2-deoxycytidine. Our findings indicate that RUNX3 methylation may occur as a common event in the development of ACC and that methylation may be a major mechanism for inactivation of RUNX3 in ACC.

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Copy and paste a formatted citation
Spandidos Publications style
Ge M, Chen C, Xu J and Ling Z: Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. Oncol Rep 26: 349-357, 2011.
APA
Ge, M., Chen, C., Xu, J., & Ling, Z. (2011). Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. Oncology Reports, 26, 349-357. https://doi.org/10.3892/or.2011.1282
MLA
Ge, M., Chen, C., Xu, J., Ling, Z."Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma". Oncology Reports 26.2 (2011): 349-357.
Chicago
Ge, M., Chen, C., Xu, J., Ling, Z."Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma". Oncology Reports 26, no. 2 (2011): 349-357. https://doi.org/10.3892/or.2011.1282
Copy and paste a formatted citation
x
Spandidos Publications style
Ge M, Chen C, Xu J and Ling Z: Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. Oncol Rep 26: 349-357, 2011.
APA
Ge, M., Chen, C., Xu, J., & Ling, Z. (2011). Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. Oncology Reports, 26, 349-357. https://doi.org/10.3892/or.2011.1282
MLA
Ge, M., Chen, C., Xu, J., Ling, Z."Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma". Oncology Reports 26.2 (2011): 349-357.
Chicago
Ge, M., Chen, C., Xu, J., Ling, Z."Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma". Oncology Reports 26, no. 2 (2011): 349-357. https://doi.org/10.3892/or.2011.1282
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