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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2011 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype

  • Authors:
    • Cristian G. Torres
    • María E. Ramírez
    • Pamela Cruz
    • María J. Epuñan
    • Luis E. Valladares
    • Walter D. Sierralta

  • View Affiliations / Copyright

    Affiliations: Laboratorio de Medicina Experimental, Escuela de Medicina Veterinaria, Universidad Andrés Bello, Santiago 8370251, Chile, Laboratorio de Nutrición y Regulación Metabólica, INTA-Universidad de Chile, El Líbano 5524, Santiago 7830489, Chile
  • Pages: 389-397
    |
    Published online on: April 28, 2011
       https://doi.org/10.3892/or.2011.1284
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Abstract

A decrease in the expression of E-cadherin and β-catenin, paralleling the loss of adherens junction complex, was observed in MCF7 cells exposed for longer than 48 h to 2 µM 27-hydroxycholesterol (27OHC), indicating an epithelial-mesenchymal transition (EMT). Upon removal of 27OHC from the culture medium, the cells released by the exposure of 72 h to the oxysterol grew as loosely packed cell groups. In these cells, accumulation of E-cadherin and β-catenin in the cytoplasm and the prolonged expression of epidermal growth factor receptor 2 (EGFR2/neu) in the plasma membrane were observed, suggesting that the acquired phenotype was related to the expression of this tyrosine kinase-growth factor receptor. The results presented here are discussed on the basis of the claimed relationship between 27OHC, hypercholesterolemia, macrophage infiltration and therapy-resistant ERα+ breast cancer incidence.

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Copy and paste a formatted citation
Spandidos Publications style
Torres CG, Ramírez ME, Cruz P, Epuñan MJ, Valladares LE and Sierralta WD: 27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. Oncol Rep 26: 389-397, 2011.
APA
Torres, C.G., Ramírez, M.E., Cruz, P., Epuñan, M.J., Valladares, L.E., & Sierralta, W.D. (2011). 27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. Oncology Reports, 26, 389-397. https://doi.org/10.3892/or.2011.1284
MLA
Torres, C. G., Ramírez, M. E., Cruz, P., Epuñan, M. J., Valladares, L. E., Sierralta, W. D."27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype". Oncology Reports 26.2 (2011): 389-397.
Chicago
Torres, C. G., Ramírez, M. E., Cruz, P., Epuñan, M. J., Valladares, L. E., Sierralta, W. D."27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype". Oncology Reports 26, no. 2 (2011): 389-397. https://doi.org/10.3892/or.2011.1284
Copy and paste a formatted citation
x
Spandidos Publications style
Torres CG, Ramírez ME, Cruz P, Epuñan MJ, Valladares LE and Sierralta WD: 27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. Oncol Rep 26: 389-397, 2011.
APA
Torres, C.G., Ramírez, M.E., Cruz, P., Epuñan, M.J., Valladares, L.E., & Sierralta, W.D. (2011). 27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. Oncology Reports, 26, 389-397. https://doi.org/10.3892/or.2011.1284
MLA
Torres, C. G., Ramírez, M. E., Cruz, P., Epuñan, M. J., Valladares, L. E., Sierralta, W. D."27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype". Oncology Reports 26.2 (2011): 389-397.
Chicago
Torres, C. G., Ramírez, M. E., Cruz, P., Epuñan, M. J., Valladares, L. E., Sierralta, W. D."27-Hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype". Oncology Reports 26, no. 2 (2011): 389-397. https://doi.org/10.3892/or.2011.1284
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