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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2011 Volume 26 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells

  • Authors:
    • Qing Sun
    • Jing Wang
    • Jun Xiong
    • Ling Yang
    • Houqi Liu

  • View Affiliations / Copyright

    Affiliations: Department of Embryology and Histology, Second Military Medical University, Shanghai 200433, P.R. China
  • Pages: 399-404
    |
    Published online on: April 29, 2011
       https://doi.org/10.3892/or.2011.1289
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Abstract

The leukemia inhibitory factor (LIF) affects multiple types of leukemia cells in vitro through the functional LIF receptor (LIFR), which comprises a complex of the LIFR α-chain (LIFR α) and gp130. As Jak2/STAT3 has been proven to be a significant mediator in the LIF-induced differentiation of promyeloid leukemia cells, we constructed a recombinant vector, pcDNA3.0-CT3 (containing the structurally conserved triple YXXQ motifs of LIFR α, termed LIFR α-CT3), and its specific tyrosine-mutated counterpart, pcDNA3.0-MUT, to determine the sites and examine the corresponding mechanisms involved in STAT3 phosphorylation. We found that the triple YXXQ motifs of LIFR α-CT3 are capable of up-regulating phosphorylated levels of STAT3 in a Jak2-independent manner prior to the induction of myeloid differentiation by LIFR α-CT3 in the human promyeloid cell line HL-60. By specifically blocking Jak2 using the AG-490 inhibitor, we observed that the LIFR α-CT3 group of HL-60 cells still demonstrated up-regulation of phosphorylated STAT3 and this up-regulation could result in the myeloid differentiation of HL-60 cells. These results may shed light on acute promyeloid leukemia therapy in future clinical practice.

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Copy and paste a formatted citation
Spandidos Publications style
Sun Q, Wang J, Xiong J, Yang L and Liu H: Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells. Oncol Rep 26: 399-404, 2011.
APA
Sun, Q., Wang, J., Xiong, J., Yang, L., & Liu, H. (2011). Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells. Oncology Reports, 26, 399-404. https://doi.org/10.3892/or.2011.1289
MLA
Sun, Q., Wang, J., Xiong, J., Yang, L., Liu, H."Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells". Oncology Reports 26.2 (2011): 399-404.
Chicago
Sun, Q., Wang, J., Xiong, J., Yang, L., Liu, H."Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells". Oncology Reports 26, no. 2 (2011): 399-404. https://doi.org/10.3892/or.2011.1289
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Q, Wang J, Xiong J, Yang L and Liu H: Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells. Oncol Rep 26: 399-404, 2011.
APA
Sun, Q., Wang, J., Xiong, J., Yang, L., & Liu, H. (2011). Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells. Oncology Reports, 26, 399-404. https://doi.org/10.3892/or.2011.1289
MLA
Sun, Q., Wang, J., Xiong, J., Yang, L., Liu, H."Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells". Oncology Reports 26.2 (2011): 399-404.
Chicago
Sun, Q., Wang, J., Xiong, J., Yang, L., Liu, H."Free LIF receptor α-chain distal cytoplasmic motifs enhance Jak2-independent STAT3 phosphorylation and induce differentiation in HL-60 cells". Oncology Reports 26, no. 2 (2011): 399-404. https://doi.org/10.3892/or.2011.1289
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