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TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway

  • Authors:
    • Yan Li
    • Lei Bian
    • Fengde Cui
    • Liangchang Li
    • Xuewu Zhang

  • View Affiliations

  • Published online on: May 31, 2011     https://doi.org/10.3892/or.2011.1330
  • Pages: 651-657
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed that TTF1 both inhibited cell growth and induced apoptosis. RT-PCR and Western blot analysis showed that TTF1 treatment led to decreased transcription and protein expression of bcl-2 and an increase in bax, Cyt-c, caspase-3 and caspase-9. These results together suggest that TTF1 may induce apoptosis of HepG-2 cells through a mitochondrial pathway.

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Journal Cover

September 2011
Volume 26 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Li Y, Bian L, Cui F, Li L and Zhang X: TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway. Oncol Rep 26: 651-657, 2011
APA
Li, Y., Bian, L., Cui, F., Li, L., & Zhang, X. (2011). TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway. Oncology Reports, 26, 651-657. https://doi.org/10.3892/or.2011.1330
MLA
Li, Y., Bian, L., Cui, F., Li, L., Zhang, X."TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway". Oncology Reports 26.3 (2011): 651-657.
Chicago
Li, Y., Bian, L., Cui, F., Li, L., Zhang, X."TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway". Oncology Reports 26, no. 3 (2011): 651-657. https://doi.org/10.3892/or.2011.1330