Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation

  • Authors:
    • Yi-Ran Cai
    • Hai-Qing Zhang
    • Yang Qu
    • Jing Mu
    • Dan Zhao
    • Li-Juan Zhou
    • Hong Yan
    • Jian-Wei Ye
    • Yan Liu
  • View Affiliations

  • Published online on: June 15, 2011     https://doi.org/10.3892/or.2011.1349
  • Pages: 877-885
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Abstract

Non-small cell lung carcinoma (NSCLC) is a leading cause of cancer-related deaths. Aberrance of the two oncogenes MET and SOX2 are frequently encountered in NSCLC. Exons 18 through 21 of the EGFR gene were screened and MET and SOX2 immunostaining was conducted to analyze the immunohistological staining of MET and SOX2 and the EGFR mutation status. One hundred and fifty tissue samples were examined including 57 squamous cell carcinomas (SCCs), 80 adenocarcinomas (ADCs), 9 adenosquamous carcinomas (ADSCs) and 4 large cell carcinomas (LCCs). The 32 NSCLCs harboring an EGFR mutation included 28 ADCs, 3 SCCs and 1 ADSC. A higher level of SOX2 expression appeared in NSCLCs without the EGFR mutation compared to those with EGFR mutation (χ2=9.02, P=0.0027). Of the 28 ADCs, 24 (85.7%) with an EGFR mutation showed low level of SOX2 expression. ADCs with deletion in exon 19 overexpressed MET and showed low levels of SOX2. SOX2 expression was inversely correlated to the expression of MET in NSCLC and mainly present in non-mutated NSCLC (r=-0.42, P<0.0001). There was a tendency for SOX2 to be expressed in SCCs and particularly in the part of SCC among ADSCs, whereas MET was mainly expressed in the part of ADC among ADSCs and ADCs. High level of MET and SOX2 expression were respectively demonstrated in ADCs and SCCs; MET activation was accompanied with exon 19 deletion in ADCs. EGFR and MET coordinate to drive tumorigenesis. Detection of the activation of MET and EGFR may be used for targeted drug therapy.

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October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cai Y, Zhang H, Qu Y, Mu J, Zhao D, Zhou L, Yan H, Ye J and Liu Y: Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation. Oncol Rep 26: 877-885, 2011
APA
Cai, Y., Zhang, H., Qu, Y., Mu, J., Zhao, D., Zhou, L. ... Liu, Y. (2011). Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation. Oncology Reports, 26, 877-885. https://doi.org/10.3892/or.2011.1349
MLA
Cai, Y., Zhang, H., Qu, Y., Mu, J., Zhao, D., Zhou, L., Yan, H., Ye, J., Liu, Y."Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation". Oncology Reports 26.4 (2011): 877-885.
Chicago
Cai, Y., Zhang, H., Qu, Y., Mu, J., Zhao, D., Zhou, L., Yan, H., Ye, J., Liu, Y."Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation". Oncology Reports 26, no. 4 (2011): 877-885. https://doi.org/10.3892/or.2011.1349