Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer

  • Authors:
    • Daniele Campa
    • Anika Hüsing
    • Lucie Dostal
    • Angelika Stein
    • Dagmar Drogan
    • Heiner Boeing
    • Anne Tjønneland
    • Nina Roswall
    • Jane Nautrup Østergaard
    • Kim Overvad
    • Laudina Rodríguez
    • Catalina Bonet
    • Maria-José Sánchez
    • Nerea Larrañaga
    • José María Huerta
    • Eva Ardanaz
    • Kay-Tee Khaw
    • Nicholas Wareham
    • Ruth C. Travis
    • Naomi E. Allen
    • Antonia Trichopoulou
    • Dimosthenis Zylis
    • Tina Karapetyan
    • Domenico Palli
    • Sabina Sieri
    • Rosario Tumino
    • Paolo Vineis
    • H. Bas Bueno-de-Mesquita
    • Per Lenner
    • Mattias Johansson
    • Mazda Jenab
    • David Cox
    • Afshan Siddiq
    • Rudolf Kaaks
    • Federico Canzian
  • View Affiliations

  • Published online on: June 24, 2011     https://doi.org/10.3892/or.2011.1359
  • Pages: 979-986
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Abstract

Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor suppression, cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and plays a pivotal role in promoting longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in response to cellular stimulation by growth factors or insulin and has been proposed as a bridge between ageing and tumor suppression. Three SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have been shown to be strongly and consistently associated with longevity, were examined in relation to PC risk in a case control study of 1571 incident PC cases and 1840 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). There was no statistically significant association between the SNPs and PC risk regardless of the model of inheritance (dominant, codomi­nant and recessive). The associations were not modified by disease aggressiveness, circulating levels of steroid sex hormones, or IGFs or BMI. We conclude that polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for PC risk, in this population of Caucasian men.

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October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Campa D, Hüsing A, Dostal L, Stein A, Drogan D, Boeing H, Tjønneland A, Roswall N, Østergaard JN, Overvad K, Overvad K, et al: Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer. Oncol Rep 26: 979-986, 2011
APA
Campa, D., Hüsing, A., Dostal, L., Stein, A., Drogan, D., Boeing, H. ... Canzian, F. (2011). Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer. Oncology Reports, 26, 979-986. https://doi.org/10.3892/or.2011.1359
MLA
Campa, D., Hüsing, A., Dostal, L., Stein, A., Drogan, D., Boeing, H., Tjønneland, A., Roswall, N., Østergaard, J. N., Overvad, K., Rodríguez, L., Bonet, C., Sánchez, M., Larrañaga, N., Huerta, J. M., Ardanaz, E., Khaw, K., Wareham, N., Travis, R. C., Allen, N. E., Trichopoulou, A., Zylis, D., Karapetyan, T., Palli, D., Sieri, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Lenner, P., Johansson, M., Jenab, M., Cox, D., Siddiq, A., Kaaks, R., Canzian, F."Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer". Oncology Reports 26.4 (2011): 979-986.
Chicago
Campa, D., Hüsing, A., Dostal, L., Stein, A., Drogan, D., Boeing, H., Tjønneland, A., Roswall, N., Østergaard, J. N., Overvad, K., Rodríguez, L., Bonet, C., Sánchez, M., Larrañaga, N., Huerta, J. M., Ardanaz, E., Khaw, K., Wareham, N., Travis, R. C., Allen, N. E., Trichopoulou, A., Zylis, D., Karapetyan, T., Palli, D., Sieri, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Lenner, P., Johansson, M., Jenab, M., Cox, D., Siddiq, A., Kaaks, R., Canzian, F."Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer". Oncology Reports 26, no. 4 (2011): 979-986. https://doi.org/10.3892/or.2011.1359