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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 26 Issue 5

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Article

RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation

  • Authors:
    • Zhen-Ning Tang
    • Fan Zhang
    • Peng Tang
    • Xiao-Wei Qi
    • Jun Jiang

  • View Affiliations / Copyright

    Affiliations: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China, Breast Disease Center, Southwest Hospital, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, P.R. China
  • Pages: 1243-1250
    |
    Published online on: June 30, 2011
       https://doi.org/10.3892/or.2011.1368
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Abstract

Accumulating studies have shown that the receptor activator of nuclear factor-κB ligand (RANKL)/RANK pathway plays an important role in tumor metastasis. However, the involvement of the RANKL/RANK signal transduction pathway in breast cancer metastasis remains unclear. The present study, therefore, investigated the role of downstream molecules of RANKL/RANK signaling in breast cancer cells using Transwell chemotaxis assays. RANKL was shown to direct the migration of MDA-MB-231 breast cancer cells. Osteoprotegerin (OPG; soluble decoy receptor of RANKL) inhibited RANKL-induced migration. RANKL activated Src kinase in MDA-MB-231 cells, as shown by Western blotting, and pretreatment with a Src inhibitor abrogated RANKL-induced cell migration, in a similar manner to OPG. Short-hairpin RNA against RANK, delivered via a lentiviral vector, significantly abolished the expression of phosphorylated Src. Stimulation by RANKL induced the phosphorylation of mitogen-activated protein kinases (MAPKs) (ERK, p38, JNK), and specific inhibitors of MAPKs blocked RANKL-induced cell migration. Furthermore, the expression of phosphorylated MAPKs could be blocked by a Src inhibitor and by small interfering RNA against Src. These findings suggest that Src and MAPK pathways may be involved in RANKL-induced MDA-MB-231 breast cancer cell migration.

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Copy and paste a formatted citation
Spandidos Publications style
Tang Z, Zhang F, Tang P, Qi X and Jiang J: RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation. Oncol Rep 26: 1243-1250, 2011.
APA
Tang , Z., Zhang, F., Tang, P., Qi, X., & Jiang, J. (2011). RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation. Oncology Reports, 26, 1243-1250. https://doi.org/10.3892/or.2011.1368
MLA
Tang , Z., Zhang, F., Tang, P., Qi, X., Jiang, J."RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation". Oncology Reports 26.5 (2011): 1243-1250.
Chicago
Tang , Z., Zhang, F., Tang, P., Qi, X., Jiang, J."RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation". Oncology Reports 26, no. 5 (2011): 1243-1250. https://doi.org/10.3892/or.2011.1368
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Z, Zhang F, Tang P, Qi X and Jiang J: RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation. Oncol Rep 26: 1243-1250, 2011.
APA
Tang , Z., Zhang, F., Tang, P., Qi, X., & Jiang, J. (2011). RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation. Oncology Reports, 26, 1243-1250. https://doi.org/10.3892/or.2011.1368
MLA
Tang , Z., Zhang, F., Tang, P., Qi, X., Jiang, J."RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation". Oncology Reports 26.5 (2011): 1243-1250.
Chicago
Tang , Z., Zhang, F., Tang, P., Qi, X., Jiang, J."RANKL-induced migration of MDA-MB-231 human breast cancer cells via Src and MAPK activation". Oncology Reports 26, no. 5 (2011): 1243-1250. https://doi.org/10.3892/or.2011.1368
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