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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2011 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4

  • Authors:
    • Guimiao Lin
    • Lijuan Zhao
    • Feng Yin
    • Rongfeng Lan
    • Lianbo Li
    • Xiaoming Zhang
    • Hui Zhang
    • Baoxue Yang

  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Norman Bethune Medical School, Jilin University, Changchun 130021, P.R. China, Department of Pharmaco­logy, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China
  • Pages: 893-899
    |
    Published online on: July 1, 2011
       https://doi.org/10.3892/or.2011.1376
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Abstract

T-cell factor 3 (TCF3), a downstream effector of Wnt signaling in embryonic stem (ES) cells, plays an important role in pluripotent self-renewal and proliferation. Loss of TCF3 delays the differentiation of mouse ES cells. The purpose of this study was to investigate the effect of TCF3 on embryonal carcinoma (EC). The mouse F9 EC cell line and a tumor-bearing mouse model were used to evaluate the anti-EC tumor effects of TCF3 in vitro and in vivo, respectively. The overexpression of TCF3 significantly inhibited proliferation, colony-forming and migration in F9 EC cells by approximately 30, 45 and 30%, respectively. The in vivo mouse model showed that the overexpression of TCF3 significantly reduced tumor volume (36.4%) and tumor weight (34.8%), malignancy progression and local infiltration and prolonged the life span of tumor-bearing mice. Overexpression of TCF3 significantly down-regulated Oct4 expression in the F9 EC cells. The results indicate that TCF3 is an inhibitor of the malignant phenotypes of embryonal carcinoma through the regulation of Oct4 expression.

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Copy and paste a formatted citation
Spandidos Publications style
Lin G, Zhao L, Yin F, Lan R, Li L, Zhang X, Zhang H and Yang B: TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4. Oncol Rep 26: 893-899, 2011.
APA
Lin, G., Zhao, L., Yin, F., Lan, R., Li, L., Zhang, X. ... Yang, B. (2011). TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4. Oncology Reports, 26, 893-899. https://doi.org/10.3892/or.2011.1376
MLA
Lin, G., Zhao, L., Yin, F., Lan, R., Li, L., Zhang, X., Zhang, H., Yang, B."TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4". Oncology Reports 26.4 (2011): 893-899.
Chicago
Lin, G., Zhao, L., Yin, F., Lan, R., Li, L., Zhang, X., Zhang, H., Yang, B."TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4". Oncology Reports 26, no. 4 (2011): 893-899. https://doi.org/10.3892/or.2011.1376
Copy and paste a formatted citation
x
Spandidos Publications style
Lin G, Zhao L, Yin F, Lan R, Li L, Zhang X, Zhang H and Yang B: TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4. Oncol Rep 26: 893-899, 2011.
APA
Lin, G., Zhao, L., Yin, F., Lan, R., Li, L., Zhang, X. ... Yang, B. (2011). TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4. Oncology Reports, 26, 893-899. https://doi.org/10.3892/or.2011.1376
MLA
Lin, G., Zhao, L., Yin, F., Lan, R., Li, L., Zhang, X., Zhang, H., Yang, B."TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4". Oncology Reports 26.4 (2011): 893-899.
Chicago
Lin, G., Zhao, L., Yin, F., Lan, R., Li, L., Zhang, X., Zhang, H., Yang, B."TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4". Oncology Reports 26, no. 4 (2011): 893-899. https://doi.org/10.3892/or.2011.1376
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