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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil

  • Authors:
    • Tie-Qiang Bi
    • Xiang-Ming Che
    • Xin-Hua Liao
    • Dan-Jie Zhang
    • Hou-Long Long
    • Hai-Jun Li
    • Wei Zhao

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. China, Department of General Surgery, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Yanta West Road 277, Xi'an 710061, P.R. China
  • Pages: 1251-1257
    |
    Published online on: July 4, 2011
       https://doi.org/10.3892/or.2011.1378
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Abstract

Nicotinamide phosphoribosyltransferase (Nampt), an enzyme involved in the NAD+ salvage pathway, is over­expressed and important in the carcinogenesis in several types of cancers. The expression of Nampt and its role in gastric cancer remain largely unknown. In this study, using real-time PCR and Western blotting we found that Nampt was overexpressed at the mRNA and protein levels, respectively, in established gastric cancer cells and human gastric cancer tissues. The specific Nampt inhibitor FK866 repressed gastric cancer cell proliferation, as assessed by MTT assay. Using transwell and soft agar clonogenic assays, we also found that FK866 suppressed gastric cancer cell migration and anchorage-independent growth, respectively. These inhibitory effects of FK866 were accompanied by significantly decreased expression of VEGF, MMP2, MMP9 and NF-κB. As determined by MTT assay and flow cytometry, FK866 also increased the chemo­sensitivity of gastric cancer cells to fluorouracil by greater inhibition of cell proliferation and the induction of apoptosis. Our findings indicate that Nampt may be a new therapeutic target for gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Bi T, Che X, Liao X, Zhang D, Long H, Li H and Zhao W: Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil. Oncol Rep 26: 1251-1257, 2011.
APA
Bi, T., Che, X., Liao, X., Zhang, D., Long, H., Li, H., & Zhao, W. (2011). Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil. Oncology Reports, 26, 1251-1257. https://doi.org/10.3892/or.2011.1378
MLA
Bi, T., Che, X., Liao, X., Zhang, D., Long, H., Li, H., Zhao, W."Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil". Oncology Reports 26.5 (2011): 1251-1257.
Chicago
Bi, T., Che, X., Liao, X., Zhang, D., Long, H., Li, H., Zhao, W."Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil". Oncology Reports 26, no. 5 (2011): 1251-1257. https://doi.org/10.3892/or.2011.1378
Copy and paste a formatted citation
x
Spandidos Publications style
Bi T, Che X, Liao X, Zhang D, Long H, Li H and Zhao W: Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil. Oncol Rep 26: 1251-1257, 2011.
APA
Bi, T., Che, X., Liao, X., Zhang, D., Long, H., Li, H., & Zhao, W. (2011). Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil. Oncology Reports, 26, 1251-1257. https://doi.org/10.3892/or.2011.1378
MLA
Bi, T., Che, X., Liao, X., Zhang, D., Long, H., Li, H., Zhao, W."Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil". Oncology Reports 26.5 (2011): 1251-1257.
Chicago
Bi, T., Che, X., Liao, X., Zhang, D., Long, H., Li, H., Zhao, W."Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil". Oncology Reports 26, no. 5 (2011): 1251-1257. https://doi.org/10.3892/or.2011.1378
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