Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome

  • Authors:
    • Alice Gerloff
    • Angela Dittmer
    • Ilka Oerlecke
    • Hans-Jürgen Holzhausen
    • Jürgen Dittmer
  • View Affiliations

  • Published online on: August 2, 2011     https://doi.org/10.3892/or.2011.1409
  • Pages: 1121-1125
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Several members of the Ets (E26 transformation specific) transcription factor family are involved in tumor progression, e.g. by activating matrix metalloproteases. Ets proteins share a unique DNA-binding domain, the Ets domain, which specifically recognizes GGAA/T-containing sequences common in many promoters. While the roles of quite a number of Ets proteins in carcinogenesis have been well established, little is known about the importance of the Ets protein Elf-1 (E74-like factor 1) in cancer. Herein, we analyzed the expression of Elf-1 in breast cancer. We found that, like T-cells, breast cancer cells express both the 80 and 98 kDa isoforms of the Elf-1 protein with the 98 kDa isoform only be present in the nucleus. Immunohistochemical analysis of 119 breast cancer biopsies showed anti-Elf-1 immunoreactivity exclusively in the nucleus. Elf-1 expression varied largely among the breast cancer samples showing a negative correlation with histological grading. However, no association of Elf-1 expression with clinical outcome was observed, even when sub-cohorts of patients who received either only adjuvant endocrine treatment or only chemotherapy were separately analyzed. These data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients.

Related Articles

Journal Cover

November 2011
Volume 26 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gerloff A, Dittmer A, Oerlecke I, Holzhausen H and Dittmer J: Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome. Oncol Rep 26: 1121-1125, 2011.
APA
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., & Dittmer, J. (2011). Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome. Oncology Reports, 26, 1121-1125. https://doi.org/10.3892/or.2011.1409
MLA
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., Dittmer, J."Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome". Oncology Reports 26.5 (2011): 1121-1125.
Chicago
Gerloff, A., Dittmer, A., Oerlecke, I., Holzhausen, H., Dittmer, J."Protein expression of the Ets transcription factor Elf-1 in breast cancer cells is negatively correlated with histological grading, but not with clinical outcome". Oncology Reports 26, no. 5 (2011): 1121-1125. https://doi.org/10.3892/or.2011.1409